Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Tacrolimus Oral Suspension    1 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    tacrolimus  5 mg  CAP   
    Water, sterile        
    Ora-Plus® / Ora-Sweet®  1:1  SYRUP  qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: HAZARDOUS - Potential
Refer to the AHS Hazardous Medication Handling Guide for more information.

1. Empty contents of capsules into mortar and levigate with water to make a paste.
2. Mix Ora-Plus® and Ora-Sweet® together (1:1) to make vehicle.
3. Gradually levigate paste with vehicle until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with vehicle.
6. Transfer to final container and label.

Notes References tested and used Prograf® brand.
Ora-Blend® may be substituted for Ora-Plus®/Ora-Sweet®.

Store in glass or NON-PVC plastic amber bottles or oral syringes.

Packaging:  glass or NON-PVC plastic amber bottles or oral syringes

Auxiliary Labels: Hazardous medication - use safe handling precautions
  Note Strength
  Protect From Light
  Shake Well
  Store at Room Temperature

Storage/Expiry:Room Temperature: 120 days

Last Date Revised: 3-Dec-21

References: AHS Hazardous Medication Handling information available on Insite:

Elefante A, Muindi J, West K, Dunford L, Abel S, et al. Long-term stability of a patient-convenient 1 mg/mL suspension of tacrolimus for accurate maintenance of stable therapeutic levels. Bone Marrow Transplant 2006; 37:781-784.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist

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