Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
valACYclovir Oral Suspension   50 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    valacyclovir  500 mg  TAB   
    Ora-Plus®    SYRUP   
    Ora-Sweet® vehicle      qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. In a mortar, crush tablets and triturate to a fine powder.
2. Gradually levigate powder with Ora-Plus® until a liquid is formed.
3. Pour into a graduated cylinder.
4. Rinse mortar and qs to final volume with Ora-Sweet®.
5. Transfer to final container and label.

Notes If tablets are difficult to crush:

1. Place tablets in mortar and crush to a powder, in batches if necessary.
2. Dissolve small amounts of the powder in water (approximately 5 mL total) over 5 to 10 minutes and grind to form a smooth paste.
3. Follow remaining steps in Directions section.

OR

1. Place tablets in mortar and soak in a small amount of water (approximately 5 mL) for 5 to 10 minutes.
2. Once tablets are sufficiently softened/dissolved, grind tablets to form a smooth paste.
3. Follow remaining steps in Directions section.

Ora-Sweet SF® can be used instead of Ora-Sweet®.

Ora-Sweet SF® should not be used in neonates less than or equal to 28 days corrected age.

Packaging:  Amber Glass Bottle

Auxiliary Labels: Refrigerate
  Shake Well

Storage/Expiry:Refrigerator: 21 days

Last Date Revised: 23-Oct-17

References:Martindale: The Complete Drug Reference [database in Lexicomp]. Hudson, OH: Lexicomp Inc. c.1978 - [cited date]. Available from: http://hinc.lib.ucalgary.ca/login?url=http://online.lexi.com

Formulations: Valacyclovir 50-mg/mL oral liquid. International Journal of Pharmaceutical Compounding 2006; 10(6):461.

Fish DN. Vidaurri VA. Deeter RG. Stability of valacyclovir hydrochloride in extemporaneously prepared oral liquids. Am J Health-Syst Pharm 1999; 56:1957-1960.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   6-Dec-2021         


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