Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Sildenafil Oral Suspension    2.5 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    sildenafil  20 mg  TAB   
    Ora-Plus® / Ora-Sweet®  1:1  SYRUP  qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. In a mortar, crush tablets and triturate to a FINE powder.
2. Mix Ora-Plus® and Ora-Sweet® together (1:1) to make vehicle.
3. Gradually levigate powder with vehicle until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with vehicle.
6. Transfer to final container and label.

Notes NOTE:
Only Revatio®, Apo-Sildenafil R tablets and Alberta Health approved interchangeable generic products covered by Province Wide Services for the treatment of primary pulmonary hypertension and are formulary. Viagra® tablets are not covered by Province Wide Services and are non-formulary.
Refer to Sildenafil tablets on AHS Provincial Formulary.

May substitute Ora Plus® / Ora Sweet® (1:1) with any of the following vehicles:
- Ora-Blend®
- Methylcellulose 1% (preserved with parabens)/ Simple Syrup (1:1)

Ensure tablets are in a FINE powder form prior to levigating with liquid mixture to prevent flecks of coating from the tablets appearing in the final suspension.

Alternatively, tablets can be soaked in enough Ora-Plus® and Ora-Sweet® (1:1) to cover tablets and allowed to sit for 40 minutes until tablets soften. Triturate mixture to form a paste and add Ora-Plus® and Ora-Sweet® (1:1) to qs to final required volume.

Packaging: 100 mL Amber Plastic Bottle

Auxiliary Labels: Can be stored at room temperature or refrigerated
  Shake Well

Storage/Expiry:Refrigerator or Room Temperature: 91 days

Last Date Revised: 25-Jan-21

References:Nahata MC. Morosco RS. Brady MT. Extemporaneous sildenafil citrate oral suspensions for the treatment of pulmonary hypertension in children. Am J Health-Syst Pharm 2006; 63(3): 254-257.

Formulations: Sildenafil citrate 2.5-mg/mL oral liquid. International Journal of Pharmaceutical Compounding. 2006; 10(4):306.

Formulations: Sildenafil citrate 2.5-mg/mL in Ora-Plus:Ora-Sweet. International Journal of Pharmaceutical Compounding. 2019;23(3):236.

Nahata MC. Extended stability of morphine and sildenafil for oral use in infants and young children. International Journal of Pharmaceutical Compounding 2016;20(3):247-249.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist

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