Recipe - Compounding Worksheet
Unauthorized distribution, copying or disclosure prohibited.
These recipes are intended for use by the pharmacy manufacturing departments only.
amLODIPine Oral Suspension   1 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    amlodipine  10 mg  TAB   
    Ora-Plus® / Ora-Sweet®  1:1  SYRUP  qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. In a mortar, crush tablets and triturate to a fine powder.
2. Mix Ora-Plus® and Ora-Sweet® together (1:1) to make vehicle.
3. Gradually levigate powder with vehicle until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to the final volume with vehicle.
6. Transfer to final container and label.

Notes May substitute Ora-Plus® / Ora-Sweet® (1:1) with any of the following vehicles:
- Ora-Blend®
- Methylcellulose 1% (preserved with parabens)/ Simple Syrup (1:1)

An expiry date of 91 days refrigerated was assigned based on the stability study from Nahata reference. Room temperature storage not included/ recommended due to risk of microbial contamination (see Reference Section).

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Refrigerate
  Shake Well

Storage/Expiry:Refrigerator: 91 days (see Reference Section)

Last Date Revised: 9-Aug-16

References:Nahata MC. Morosco RS. Hipple TF. Stability of amlodipine besylate in two liquid dosage forms. J Am Pharm Assoc 1999; 39:375-377.
Recommended a stablilty of 91 days refrigerated and 56 days at room temperature with Ora-Plus®/ Ora-Sweet® (1:1) or Methylcellulose 1%/ Simple Syrup (1:1).

Lyszkiewicz DA. Levichek Z. Kozer E. Yagev Y. Moretti M. Hard M. Koren G. Bioavailability of a pediatric amlodipine suspension. Pediatr Nephrol 2003; 18:675-678.
Questioned the stability of this suspension stored at room temperature, but this was not the original purpose of the study. Original purpose was to compare the bioavailability of the tablets vs the suspension.

Children's Hospital of Eastern Ontario. Amlodipine 1 mg/mL oral suspension: Master Formula Sheet (last updated Nov 2006).
Assigned a stability of 91 days refrigerated and 56 days at room temperature.

Nationwide Children's Hospital, Columbus Ohio. Amlodipine 1 mg/mL oral suspension recipe (last updated March 2010).
Assigned a stability of 91 days refrigerated and 56 days at room temperature.
 
Nahata MC, Pai VB, Hipple TF. Pediatric drug formulations. 5th ed. Cincinnati, OH: Harvey Whitney Books Company; 2003.
  Amlodipine 1 mg/mL oral suspension recipe (last updated April 2007).
Assigned a stability of 30 days refrigerated with Ora-Plus®/ Ora-Sweet® vehicle.
Nahata MC, Pai VB, Hipple TF. Pediatric drug formulations. 5th ed. Cincinnati, OH: Harvey Whitney Books Company; 2003.
  Recommended a stability of 30 days refrigerated.
Nahata MC, Pai VB, Hipple TF. Pediatric drug formulations. 5th ed. Cincinnati, OH: Harvey Whitney Books Company; 2003.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   29-Nov-2021         


This content is provided for general information purposes only. It is not intended to replace consultations with a health care professional or to provide medical advice, diagnosis or treatment. Always seek the advice of a physician or other qualified health care provider with any medical or health questions. Alberta Health Services accepts no responsibility for any modification or redistribution of this document and is not liable for any actions taken by individuals based on the information provided, or for any inaccuracies, errors, or omissions in the information in this document. These recipes are to be used as a reference and are not intended to be master formulation records. Not all recipes may be compliant with NAPRA or other standards.