Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Ursodiol Oral Suspension    50 mg/mL *Note Strength*
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    ursodiol  250 mg  TAB   
    Ora-Plus® / Ora-Sweet®  1:1  SYRUP  qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. In a mortar, crush tablets and triturate to a fine powder.
2. Mix Ora-Plus® and Ora-Sweet® together (1:1) to make vehicle.
3. Gradually levigate powder with vehicle until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with vehicle.
6. Transfer to final container and label.

Notes May substitute Ora-Plus® / Ora-Sweet® (1:1) with any of the following vehicles:
- Ora-Blend®
- Ora-Plus® / Ora-Sweet SF® (1:1)
- Ora-Blend SF®
- Ora-Plus® / Strawberry Syrup (1:1); note strawberry syrup 4 L is prepared from 3200 mL of simple syrup and 600 mL of strawberry fountain syrup.

Ora-Sweet SF® and Ora-Blend SF® should not be used in neonates less than or equal to 28 days corrected age.

Stability information selected based on the shortest expiry date found in the references (See Reference Section).

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Can be stored at room temperature or refrigerated
  Note Strength
  Shake Well

Storage/Expiry:Refrigerator or Room Temperature: 60 days

Last Date Revised: 24-Aug-16

References:Johnson CE. Streetman DD. Stability of oral suspensions of ursodiol made from tablets. Am J Health-Syst Pharm. 2002; 59: 361-363
Ursodiol 50 mg/mL oral suspension prepared with Ora-Plus®/ Strawberry syrup (1:1) or Ora-Plus®/ Ora-Sweet SF® (1:1), stable for 90 days at room temperature or refrigerated.
  Ursodiol 50 mg/mL oral suspension (last updated April 2007).
Assigned a stability of 60 days at room temperature with Ora-Plus® /Ora-Sweet® (1:1).
SickKids Compounding Service [online recipes]. Toronto, ON: The Hospital for Sick Children. c1999 – [current date]. Available from:

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist

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