Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Pyrazinamide Oral Suspension    100 mg/mL *Note Strength*
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    pyrazinamide  500 mg  TAB   
    Simple syrup       qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. In a mortar, crush tablets and triturate to a fine powder.
2. Gradually levigate powder with simple syrup until a liquid is formed.
3. Pour into a graduated cylinder.
4. Rinse mortar and qs to final volume with simple syrup.
5. Transfer to final container and label.

Notes Recipe can also be prepared with a 1:1 mixture of simple syrup and methylcellulose 1% solution, with the same stability.

SickKids has assigned an expiry date of 42 days at room temperature in amber glass bottles for this preparation, based on their pharmacy experience (see Reference Section).

Refrigerate storage is preferred.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Can be stored at room temperature or refrigerated
  Note Strength
  Shake Well

Storage/Expiry:Refrigerator or Room Temperature: 60 days

Last Date Revised: 24-Aug-16

References:Nahata MC, Morosco RS, Peritore SP. Stability of pyrazinamide in two suspensions. Am J Health-Syst Pharm 1995 (Jul 15); 52:1558-1560.
Pyrazinamide 100 mg/mL prepared with simple syrup or methylcellulose 1%/ simple syrup (1:1), stable for 60 days at room temperature or refrigerated in amber glass or plastic bottles.
  Pyrazinamide 100 mg/mL oral suspension (last updated April 2007).
Recipe prepared with simple syrup, stable for 42 days at room temperature in amber glass bottles.
SickKids Compounding Service [online recipes]. Toronto, ON: The Hospital for Sick Children. c1999 [current date]. Available from: http://www.sickkids.ca/Pharmacy/Compounding-Service/index.html

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   29-Nov-2021         


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