Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
azaTHIOprine Oral Suspension (LOW STRENGTH)   10 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    azathioprine  50 mg  TAB   
    HSC suspending vehicle       qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Refer to the AHS Hazardous Medication Handling Guide for more information.

1. In a mortar, crush tablets and triturate into a fine powder.
2. Gradually levigate powder with HSC vehicle until a liquid is formed.
3. Pour into a graduated cylinder.
4. Rinse mortar and qs to final volume with HSC vehicle.
5. Transfer to final container and label.

Notes See recipe for HSC suspending vehicle.

Stability of 60 days refrigerated was assigned to follow the same expiration date as Azathioprine 50 mg/mL oral suspension, even though one reference (Nahata et al) assigned an arbitrary expiry date of 84 days refrigerated (not based on any stability studies).

May substitute HSC suspending vehicle with Ora-Blend®.

Refrigerated storage is preferred.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Cytotoxic
  Hazardous medication - use safe handling precautions
  Note Strength
  Shake Well

Storage/Expiry:Refrigerator or Room Temperature: 60 days

Last Date Revised: 28-Jun-19

References:AHS Hazardous Medication Handling information available on Insite:

Allen LV Jr, Erikson MA III. Stability of acetazolamide, allopurinol, azathioprine, clonazepam, and flucytosine in extemporaneously compounded oral liquids. Am J Health-Syst Pharm. 1996; 53 (Aug): 1944-1949.
  Azathioprine 10 mg/mL oral suspension prepared with methylcellulose 1% solution and simple syrup, assigned an expiry date of 84 days refrigerated or 56 days at room temperature (stability-indicating analytical methods not used).
Nahata MC, Pai VB, Hipple TF. Pediatric drug formulations. 5th ed. Cincinnati, OH: Harvey Whitney Books Company; 2003.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist

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