||1. In a mortar, crush tablets and triturate to a fine powder.
2. Gradually levigate powder with water to form a smooth paste.
3. Mix Ora-Plus® and Ora-Sweet® together (1:1) to make vehicle and levigate with paste until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with vehicle.
6. Transfer to final container and label.
||Ora-Blend® may be substituted for Ora-Plus®/ Ora-Sweet® (1:1).
Expiry date and concentration selected to prepare recipe is based on best practice and ease of calculation of dose (see Reference Section).
|| Amber Glass Bottle
||Store at Room Temperature
|Storage/Expiry:||Room Temperature: 60 days|
|Last Date Revised:
|References:||Written communication between Elita Ho, GlaxoSmithKline Medical Information Specialist and Marielle Layton, Drug Information Pharmacist, Alberta Health Services. Stability of Coreg suspensions prepared from tablets. April 20, 2004.|
Provided information that Coreg 0.1 mg/mL and 1.67 mg/mL prepared with water, Ora-Plus® and Ora-Sweet® were stable for 12 weeks (84 days) at room temperature.
Formulations: Carvedilol 1.25 mg/mL oral suspension. International Journal of Pharmaceutical Compounding 2006. 10(3):220.
Carvedilol 1.25 mg/mL oral suspension prepared with water and Ora-Blend®, stable for 84 days at room temperature.
||Carvedilol 1.67 mg/mL oral suspension (last updated April 2007).
Assigned a stability of 60 days refrigerated with Ora-Plus®/ Ora-Sweet® (1:1).
SickKids Compounding Service [online recipes]. Toronto, ON: The Hospital for Sick Children. c1999 – [current date]. Available from: http://www.sickkids.ca/Pharmacy/Compounding-Service/index.html