Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
carVEDilol Oral Suspension   1 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    carvedilol  12.5 mg  TAB   
    Water, sterile        
    Ora-Plus® / Ora-Sweet®  1:1  SYRUP  qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. In a mortar, crush tablets and triturate to a fine powder.
2. Gradually levigate powder with water to form a smooth paste.
3. Mix Ora-Plus® and Ora-Sweet® together (1:1) to make vehicle and levigate with paste until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with vehicle.
6. Transfer to final container and label.

Notes Ora-Blend® may be substituted for Ora-Plus®/ Ora-Sweet® (1:1).

Expiry date and concentration selected to prepare recipe is based on best practice and ease of calculation of dose (see Reference Section).

Packaging:  Amber Glass Bottle

Auxiliary Labels: Shake Well
  Store at Room Temperature

Storage/Expiry:Room Temperature: 60 days

Last Date Revised: 30-May-13

References:Written communication between Elita Ho, GlaxoSmithKline Medical Information Specialist and Marielle Layton, Drug Information Pharmacist, Alberta Health Services. Stability of Coreg suspensions prepared from tablets. April 20, 2004.
Provided information that Coreg 0.1 mg/mL and 1.67 mg/mL prepared with water, Ora-Plus® and Ora-Sweet® were stable for 12 weeks (84 days) at room temperature.

Formulations: Carvedilol 1.25 mg/mL oral suspension. International Journal of Pharmaceutical Compounding 2006. 10(3):220.
Carvedilol 1.25 mg/mL oral suspension prepared with water and Ora-Blend®, stable for 84 days at room temperature.
  Carvedilol 1.67 mg/mL oral suspension (last updated April 2007).
Assigned a stability of 60 days refrigerated with Ora-Plus®/ Ora-Sweet® (1:1).
SickKids Compounding Service [online recipes]. Toronto, ON: The Hospital for Sick Children. c1999 – [current date]. Available from: http://www.sickkids.ca/Pharmacy/Compounding-Service/index.html

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   6-Dec-2021         


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