Recipe - Compounding Worksheet
Unauthorized distribution, copying or disclosure prohibited.
These recipes are intended for use by the pharmacy manufacturing departments only.
Ciprofloxacin Oral Suspension in Ora-PlusŪ/ Simple Syrup    50 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    ciprofloxacin  500 mg  TAB   
    Ora-PlusŪ / Simple Syrup   1:1    qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. In a mortar, crush tablets and triturate to a fine powder.
2. Mix Ora-PlusŪ and simple syrup together (1:1) to make vehicle.
3. Gradually levigate powder with vehicle until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume.
6. Transfer to final container and label.

Notes To be prepared ONLY in the event that the commercial product is NOT available or unsuitable.

Strength of compounded formulation is different than the commercial preparation.
This strength is non-formulary.
Refer to Ciprofloxacin suspension in AHS Provincial Formulary.

Can be prepared for patients on NJ, NG or tube feeds, since the commercial product is a very thick nonaqueous granular suspension resulting in a high risk of tube blockage.

Other strengths of ciprofloxacin tablets can be used. Adjust quantity as required to make a 50 mg/mL suspension.

Recipe has a prolonged bitter aftertaste. Palatibility for oral use can be increased by mixing equal parts of chocolate syrup with the dose just prior to administration.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Can be stored at room temperature or refrigerated
  Protect From Light
  Shake Well

Storage/Expiry:Refrigerator or Room Temperature: 56 days

Last Date Revised: 6-Apr-16

References:Johnson CE. Wong DV. Hoppe HL. Bhatt-Mehta V. Stability of ciprofloxacin in an extemporaneous oral liquid dosage form. International Journal of Pharmaceutical Compounding 1998; 2(4):314-317.
Nahata MC, Pai VB, Hipple TF. Pediatric drug formulations. 5th ed. Cincinnati, OH: Harvey Whitney Books Company; 2003.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist

This content is provided for general information purposes only. It is not intended to replace consultations with a health care professional or to provide medical advice, diagnosis or treatment. Always seek the advice of a physician or other qualified health care provider with any medical or health questions. Alberta Health Services accepts no responsibility for any modification or redistribution of this document and is not liable for any actions taken by individuals based on the information provided, or for any inaccuracies, errors, or omissions in the information in this document. These recipes are to be used as a reference and are not intended to be master formulation records. Not all recipes may be compliant with NAPRA or other standards.