Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
fluCYTOsine Oral Suspension    50 mg/mL *Note Strength*
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    flucytosine   500 mg   CAP   
    Ora-Plus®/ Ora-Sweet SF®   1:1  SYRUP  qs to  
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. Empty contents of capsules into a mortar and triturate to a fine powder.
2. Mix Ora-Plus® and Ora-Sweet SF® together (1:1) to make vehicle.
3. Gradually levigate powder with vehicle until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with vehicle.
6. Transfer to final container and label.

Notes Flucytosine 500 mg capsules are available through Health Canada's Special Access Program.

May substitute Ora-Plus®/ Ora-Sweet SF® (1:1) with any of the following vehicles:
- Ora-Blend SF®
- Ora-Plus®/ Strawberry Syrup (1:1)

Ora-Sweet SF® and Ora-Blend SF® should not be used in neonates less than or equal to 28 days corrected age.

Recipe based on Vandenbussche et al study, which assigned a longer expiry time with a higher concentration/strength of flucytosine (see Reference Section).

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Can be stored at room temperature or refrigerated
  Note Strength
  Shake Well

Storage/Expiry:Refrigerator or Room Temperature: 90 days

Last Date Revised: 27-Jan-14

References:Vandenbussche HL. Johnson CE. Yun J. Patel SA. Stability of flucytosine 50 mg/mL in extemporaneous oral liquid formulations. Am J Health-Syst Pharm 2002; 59:1853-1855.
Flucytosine 50 mg/mL prepared with Ora-Plus® /Ora Sweet SF® (1:1) or Ora-Plus® /Strawberry Syrup (1:1), stable for 90 days at room temperature or refrigerated.

Allen LV, Erickson MA. Stability of acetazolamide, allopurinol, azathioprine, clonazepam, and flucytosine in extemporaneously compounded oral liquids. Am J Health-Syst Pharm 1996; 53:1944-1949.
Flucytosine 10 mg/mL prepared with Ora-Plus®/ Ora-Sweet® (1:1) or Ora-Plus®/ Ora-Sweet SF® (1:1) or Cherry Syrup in polyethylene terephthalate bottles, stable for 60 days at room temperature or refrigerated.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   6-Dec-2021         


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