Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Oseltamivir Oral Suspension in Water with 0.1% w/v Sodium Benzoate   12 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    oseltamivir  75 mg  CAP   
    Water with sodium benzoate (Preserved Water)   0.1%    qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. Empty contents of capsules into a GLASS mortar and triturate to a fine powder.
2. Gradually levigate the powder with a portion of the sodium benzoate 0.1% w/v solution.
3. Pour into a graduated cylinder.
4. Rinse mortar and qs to final volume with 0.1% sodium benzoate solution.
5. Transfer to final container and label.

Notes To be prepared ONLY in the event that the 12 mg/mL commercial product is NOT available.

A 12 mg/mL strength was chosen for this recipe to match the strength of the commercial product, TamifluŽ suspension manufactured by Roche.

See recipe for Water with Sodium Benzoate (Preserved Water) 0.1%.

The appropriate dose may be mixed just prior to administration with an equal amount of sweet liquid such as sugar water, chocolate syrup, cherry syrup or desert topping like caramel or fudge sauce to mask the bitter taste.

Information for this recipe was extrapolated from the Tamiflu European Union Summary provided by the Canadian Pharmacist Association (see Reference Section).
The summary recommended a Oseltamivir 10 mg/mL suspension prepared with 0.1% sodium benzoate with an expiry date of 3 weeks at room temperature or 6 weeks refrigerated.

A beyond use date of 14 days refrigerated was assigned based on USP 795 Pharmaceutical Compounding Non-Sterile Preparation guidelines.

THIS FORMULATION IS NOT BASED ON LITERATURE, but is from unpublished data, historical use, or physician/pharmacy experience.

Packaging: 100 mL Amber Glass Bottle

Auxiliary Labels: Refrigerate
  Shake Well

Storage/Expiry:Refrigerator: 14 days

Last Date Revised: 17-May-16

References:Canadian Pharmacist Association. H1N1 flu - CPha's update #6. October 30, 2009.
Oseltamivir suspension stored in amber glass or amber PET bottles.

USP 32, NF 27, Volume 1, Chapter 795: Pharmaceutical compounding nonsterile preparations. Rockville, MD, USA: United States Pharmacopeia Convention; 2009.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   29-Nov-2021         


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