Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Hydroxyurea Oral Suspension (LOW STRENGTH)   40 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    hydroxyurea  500 mg  CAP   
    Ora-Plus® / Ora-Sweet®  1:1  SYRUP  qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: HAZARDOUS - CYTOTOXIC
Refer to the AHS Hazardous Medication Handling Guide for more information.

1. Empty contents of capsules into a mortar and triturate to a fine powder.
2. Mix Ora-Plus® and Ora-Sweet® together (1:1) to make vehicle.
3. Gradually levigate powder with vehicle until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with vehicle.
6. Transfer to final container and label.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Antineoplastic Agent
  CHEMOTHERAPY Dispose of Properly
  Can be stored at room temperature or refrigerated
  Cytotoxic
  Hazardous medication - use safe handling precautions
  Note Strength
  Shake Well

Storage/Expiry:Refrigerator or Room Temperature: 14 days

Last Date Revised: 17-May-18

References: AHS Hazardous Medication Handling information available on Insite: http://insite.albertahealthservices.ca/17382.asp

Nahata MC, Morosco RS, & Boster EA. Stability of hydroxyurea in two extemporaneously prepared oral suspensions stored at two temperatures. ASHP Midyear Clinical Meeting 2003; 38(Dec): P-161(E).

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   29-Nov-2021         


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