Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Naltrexone Oral Suspension    5 mg/mL *Note Strength*
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    naltrexone  50 mg  TAB   
    ascorbic acid  500 mg  TAB   
    sodium benzoate    PWD   
    glycerin  100%  PO SOLN   
    Water, sterile       qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. In a mortar, crush tablets of naltrexone and ascorbic acid and triturate to a fine powder.
2. Mix in sodium benzoate powder with powder mixture and levigate with glycerin to form a paste.
3. Gradually levigate sterile water into paste to form a liquid.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with sterile water.
6. Transfer to final container and label.

Notes The final product may be filtered to improve the gritty texture and appearance.

Mixing the required dose with fruit juice or flavored drinks just prior to administration can decrease bitter taste of preparation.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Can be stored at room temperature or refrigerated
  Note Strength
  Protect From Light
  Shake Well

Storage/Expiry:Refrigerator: 60 days
  Room Temperature: 30 days

Last Date Revised: 31-Jan-18

References:Fawcett JP. Morgan NC. Woods DJ. Formulation and stability of naltrexone oral liquid for rapid withdrawal from methadone. Annals of Pharmacotherapy 1997; 31:1291-1295.
- Naltrexone 1 mg/mL suspension stable for 90 days at room temperature or refrigerated, but developed yellow discoloration. Authors recommended 60 days refrigerated or 30 days at room temperature.
- Also tested Naltrexone 5 mg/mL suspension, stable at 70°C with little difference in drug stabililty compared to the 1 mg/mL concentration. Authors suggested using higher concentration to reduce volume of bitter tasting preparation.
 
Trissel LA. Trissel’s™ Stability of compounded formulations. 4th ed. Washington, DC: American Pharmacists Association; 2009.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   6-Dec-2021         


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