Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Tranexamic Acid Nasal Gel   5% (w/w)
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    tranexamic acid  500 mg  TAB   
    Water, sterile       to wet tablets 
    SecarisŪ     GEL   
Recipe Total Quantity:
Final Quantity Desired: g

Directions: Use gloves and mask when preparing.

1. In a mortar, crush tablets and triturate to a fine powder.
2. Levigate powder with sterile water for injection to make a smooth paste.
3. Gradually add the SecarisŪ gel to the paste.
4. Pull the plunger out of a 60 mL syringe and fill the barrel with gel. Replace the plunger and transfer 1 mL of gel to a 3 mL syringe using a syringe tip connector. Cap with syringe tip cap.

Notes a) Actual concentration is about 4.5%.
b) Isopropyl alcohol was used as a wetting agent in the past.
c) Wetting agent can be omitted altogether.
d) Can be packaged in ointment jars.

Previous formulation listed Intrasite gel. Either Secaris or Intrasite gel can be used to prepare recipe.

Since no stability data available, assign beyond use date using principles of NAPRA Guidance Document For Pharmacy Compounding Of Non-Sterile Preparations: Use the most conservative approach when there is conflicting information. As such, use the more conservative historical BUD of 7 days refrigerated rather than the arbitrary NAPRA BUD.

THIS FORMULATION IS NOT BASED ON LITERATURE, but is from unpublished data, historical use or physician/pharmacy experience.

Packaging: 3 mL Syringe

Auxiliary Labels: Refrigerate

Storage/Expiry:Refrigerator: 7 days

Last Date Revised: 26-Aug-21

References:AHS Drug Information Service. Previous Question #20707. What should the BUD be for Tranexamic Acid Nasal Gel 5% (w/w)? 2020 Aug 26. Available at:
National Association of Pharmacy Regulatory Authorities (NAPRA). Guidance Document For Pharmacy Compounding Of Non-Sterile Preparations. Ottawa, ON: National Association of Pharmacy Regulatory Authorities (NAPRA); 2018.
Available at:

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist

This content is provided for general information purposes only. It is not intended to replace consultations with a health care professional or to provide medical advice, diagnosis or treatment. Always seek the advice of a physician or other qualified health care provider with any medical or health questions. Alberta Health Services accepts no responsibility for any modification or redistribution of this document and is not liable for any actions taken by individuals based on the information provided, or for any inaccuracies, errors, or omissions in the information in this document. These recipes are to be used as a reference and are not intended to be master formulation records. Not all recipes may be compliant with NAPRA or other standards.