Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Hydroxyurea Oral Suspension   100 mg/mL *Note Strength*
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    hydroxyurea  500 mg  CAP   
    Water, sterile        
    Simple syrup      qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: HAZARDOUS - CYTOTOXIC
Refer to the AHS Hazardous Medication Handling Guide for more information.

1. Empty contents of capsules into a mortar and triturate to a fine powder.
2. Gradually levigate powder with sterile water until a liquid is formed. Stir solution well; use of a magnetic stirrer is recommended.
3. Filter the solution and pour into a graduated cylinder.
4. Rinse mortar and qs to final volume with simple syrup.
5. Transfer to final container and label.

Notes Filtration is recommended to remove insoluble excipients (as per reference).
We cannot advise on the correct filter as we have no information from the original references specifying any particular filter size. If filtering is difficult, this step can be skipped as the filtering is intended to remove insoluble excipients.

The solution will crystallize if inadvertently refrigerated.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Antineoplastic Agent
  CHEMOTHERAPY Dispose of Properly
  Cytotoxic
  Hazardous medication - use safe handling precautions
  Note Strength
  Shake Well
  Store at Room Temperature

Storage/Expiry:Room Temperature: 30 days

Last Date Revised: 17-May-18

References: AHS Hazardous Medication Handling information available on Insite: http://insite.albertahealthservices.ca/17382.asp

Heeney MM, Whorton MR, Howard TA et al. Chemical and functional analysis of hydroxyurea oral solutions. J Pediatr Hematol Oncol 2004; 26(3):179-184.

Nahata MC, Pai VB, Hipple TF. Pediatric drug formulations. 6th ed. Cincinnati, OH: Harvey Whitney Books Company; 2011.

Written communication from Sainte Justine Hospital, Pharmacy Department to Alberta Children's Hospital Drug Information Pharmacist; December 12, 2011.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   29-Nov-2021         


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