Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
OLANZapine Oral Suspension   1 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    olanzapine  10 mg  TAB   
    carboxymethylcellulose     PWD   
    Parabens   10%  PO SOLN   
    Simple syrup       
    Water, sterile       qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. In a mortar, crush tablets and triturate to a fine powder.
2. Mix powder with carboxymethylcellulose.
3. Gradually levigate powder mixture with simple syrup and parabens until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with water.
6. Transfer to final container and label.

Notes See recipe for Parabens 10% oral solution.

Exact details of the composition of the base were not provided in the original article by Harvey et al., only that it contained simple syrup, carboxymethylcellulose and parabens. The composition of the base used is from Formulation in Pharmacy Practice reference.

Packaging: 100 mL Amber Plastic Bottle

Auxiliary Labels: Protect From Light
  Shake Well

Storage/Expiry:Refrigerator: 14 days

Last Date Revised: 24-Jan-14

References:Harvey EJ, Flanagan RJ, Taylor DM. The preparation and stability of a liquid olanzapine preparation for oral administration in hospitals. Pharm J 2000; 265:275-276.

Woods DJ. Formulation in pharmacy practice. 2nd ed. 2001. Dunedin, New Zealand: HealthCare Otago.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist

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