Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Mycophenolate Mofetil Oral Suspension (LOW STRENGTH)   10 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    mycophenolate mofetil  250 mg  CAP   
    Ora-Plus® / Ora-Sweet®  1:1  SYRUP  qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: HAZARDOUS - Potential
Refer to the AHS Hazardous Medication Handling Guide for more information.

1. Empty contents of capsules into a mortar and triturate to a fine powder.
2. Mix Ora-Plus® and Ora-Sweet® together (1:1) to make vehicle.
3. Gradually levigate powder with vehicle until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with vehicle.
6. Transfer to final container and label.

Notes A commercial 200 mg/mL oral formulation is available. Strength of compounded formulation is different than the commercial preparation.
This strength is non-formulary.
Refer to Mycophenolate suspension in AHS Provincial Formulary.

This recipe should only be prepared when the commercial product is not suitable for the patient.

This recipe is based on information extrapolated from the literature:
- Mycophenolate 50 mg/mL and 100 mg/mL suspensions in Ora-Plus®: Ora-Sweet® (1:1) are stable for 91 days at room temperature or refrigerated (see CJHP reference)
- Mycophenolate 50 mg/mL suspension in Ora-Plus® and Cherry syrup is stable for 210 days refrigerated (see Annals of Pharmacotherpay reference)
- Therefore, a 10 mg/mL recipe is likely to be stable for the same amount of time as the reference from CJHP, but an expiry of 30 days has been assigned since stability studies have not been completed for this strength.

THIS FORMULATION IS NOT BASED ON LITERATURE, but is from unpublished data, historical use, or physician/pharmacy experience.

Packaging: 100 mL Amber Plastic Bottle

Auxiliary Labels: Hazardous medication - use safe handling precautions
  Note Strength
  Refrigerate
  Shake Well

Storage/Expiry:Refrigerator: 30 days

Last Date Revised: 2-Dec-19

References: AHS Hazardous Medication Handling information available on Insite: http://insite.albertahealthservices.ca/17382.asp

Ensom MHH. Stability of mycophenolate in a 1:1 mixture of Ora-Sweet® and Ora-Plus®. Can J Hosp Pharm 2002 (Feb); 55(1):63-65.

Venkaratamanan R, McCombs JR, Zuckerman S, McGhee B, Pisupate J et al. Stability of mycophenolate mofetil as an extemporaneous suspension. Annals of Pharmacotherapy 1998; 32:755-757.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   6-Dec-2021         


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