Recipe - Compounding Worksheet
Unauthorized distribution, copying or disclosure prohibited.
These recipes are intended for use by the pharmacy manufacturing departments only.
capTOPRIL Oral Suspension with Ascorbic Acid   1 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    captopril  50 mg  TAB   
    ascorbic acid  500 mg  TAB   
    Water, sterile        
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. Measure water and transfer to amber bottle.
2. Add captopril and vitamin C tablets to water, and shake to dissolve.

Notes Regular non-chewable tablets of Vitamin C can be used instead of the chewable tablets. Color of final product may differ depending upon the excipients in the tablets.

Refrigerated storage is preferred.

References determined stability of suspension stored in glass bottles.

Packaging: (see Notes section) Amber Glass Bottle

Auxiliary Labels: Can be stored at room temperature or refrigerated
  Shake Well

Storage/Expiry:Refrigerator: 56 days
  Room Temperature: 28 days

Last Date Revised: 25-Jan-17

References:Nahata MC. Morosco RS. Hipple TF. Stability of captopril in liquid containing ascorbic acid or sodium ascorbate. Am J Hosp Pharm 1994; 51:1707-1708.

Walsh K. Book review: Children’s Hospital of Philadelphia Extemporaneous Formulations. Can J Hosp Pharm 2004 (Feb); 57(1):42-43.

Lowey A and Jackson M. How to ensure the quality and safety of unlicensed oral medicines. The Pharmaceutical Journal 2008; 281:240.
Nahata MC, Pai VB, Hipple TF. Pediatric drug formulations. 5th ed. Cincinnati, OH: Harvey Whitney Books Company; 2003.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist

This content is provided for general information purposes only. It is not intended to replace consultations with a health care professional or to provide medical advice, diagnosis or treatment. Always seek the advice of a physician or other qualified health care provider with any medical or health questions. Alberta Health Services accepts no responsibility for any modification or redistribution of this document and is not liable for any actions taken by individuals based on the information provided, or for any inaccuracies, errors, or omissions in the information in this document. These recipes are to be used as a reference and are not intended to be master formulation records. Not all recipes may be compliant with NAPRA or other standards.