||1. Measure water and transfer to amber bottle.
2. Add captopril and vitamin C tablets to water, and shake to dissolve.
||Regular non-chewable tablets of Vitamin C can be used instead of the chewable tablets. Color of final product may differ depending upon the excipients in the tablets.
Refrigerated storage is preferred.
References determined stability of suspension stored in glass bottles.
||(see Notes section) Amber Glass Bottle
||Can be stored at room temperature or refrigerated|
|Storage/Expiry:||Refrigerator: 56 days|
||Room Temperature: 28 days
|Last Date Revised:
|References:||Nahata MC. Morosco RS. Hipple TF. Stability of captopril in liquid containing ascorbic acid or sodium ascorbate. Am J Hosp Pharm 1994; 51:1707-1708.|
Walsh K. Book review: Children’s Hospital of Philadelphia Extemporaneous Formulations. Can J Hosp Pharm 2004 (Feb); 57(1):42-43.
Lowey A and Jackson M. How to ensure the quality and safety of unlicensed oral medicines. The Pharmaceutical Journal 2008; 281:240.
Nahata MC, Pai VB, Hipple TF. Pediatric drug formulations. 5th ed. Cincinnati, OH: Harvey Whitney Books Company; 2003.