||1. Place approximately 1/3 bottle of Nutraderm® lotion (see Notes section for list of alternative vehicles) into a mortar.
2. Empty clindamycin solution from vials or powder from capsules (see Notes) into the mortar.
3. Mix thoroughly, gradually adding remainder of lotion.
4. Transfer to final container and label.
|| Alternative vehicles:
- Nutraderm cream
- Cetaphil lotion
- Moisturel lotion
- Complex 15 lotion
- Dilusol lotion
May also use clindamycin capsules to prepare the lotion (i.e. 2.2 g clindamycin per 220 mL lotion).
Assign expiry date using USP 795 Guidelines, since no stability data available.
USP 795 guidelines - Solid Formulations:
"Where the manufactured drug product is the active ingredient source - not later than 25% of the time remaining until the preparation expiration date or 6 months, whichever is earlier.
Where USP or NF is the active ingredient source - 6 months"
THIS FORMULATION IS NOT BASED ON LITERATURE, but is from unpublished data, historical use or physician/pharmacy experience.
|| Amber Plastic Bottle
||For External Use Only|
||Store at Room Temperature
|Storage/Expiry:||Room Temperature: 6 months|
|Last Date Revised:
|References:||Foldvari M. Dermatological formulations: gels, lotions and solutions. Hosp Pharm Pract 1993 (Nov):10-12.|
USP 34 – NF 29, 2nd Volume 1. Chapter 795: Pharmaceutical compounding – Nonsterile preparations. Rockville, MD, USA: United States Pharmacopeial Convention; 2010