Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Clindamycin in Nutraderm® Lotion   10 mg/mL (1%)
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    clindamycin phosphate  150 mg/mL  INJ   
    mineral oil - surfactant  n/a  CRM  Nutraderm® Lotion  
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. Place approximately 1/3 bottle of Nutraderm® lotion (see Notes section for list of alternative vehicles) into a mortar.
2. Empty clindamycin solution from vials or powder from capsules (see Notes) into the mortar.
3. Mix thoroughly, gradually adding remainder of lotion.
4. Transfer to final container and label.

Notes Alternative vehicles:
- Nutraderm cream
- Cetaphil lotion
- Moisturel lotion
- Complex 15 lotion
- Dilusol lotion

May also use clindamycin capsules to prepare the lotion (i.e. 2.2 g clindamycin per 220 mL lotion).

Assign expiry date using USP 795 Guidelines, since no stability data available.
USP 795 guidelines - Solid Formulations:
"Where the manufactured drug product is the active ingredient source - not later than 25% of the time remaining until the preparation expiration date or 6 months, whichever is earlier.
Where USP or NF is the active ingredient source - 6 months"

THIS FORMULATION IS NOT BASED ON LITERATURE, but is from unpublished data, historical use or physician/pharmacy experience.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: For External Use Only
  Shake Well
  Store at Room Temperature

Storage/Expiry:Room Temperature: 6 months

Last Date Revised: 25-Oct-16

References:Foldvari M. Dermatological formulations: gels, lotions and solutions. Hosp Pharm Pract 1993 (Nov):10-12.
 
USP 34 – NF 29, 2nd Volume 1. Chapter 795: Pharmaceutical compounding – Nonsterile preparations. Rockville, MD, USA: United States Pharmacopeial Convention; 2010

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   29-Nov-2021         


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