Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Phosphate, anhydrous (Joulie's) Oral Solution   45 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    phosphorus (sodium phosphate dibasic, anhydrous)    PWD   
    phosphoric acid (H3PO4)  85%    57.8 g = 34 mL 
    Water, sterile       qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. Place magnetic stirrer in calibrated beaker.
2. Add approximately 90% of the final volume of sterile water.
3. Place beaker on hot plate. Turn on stirrer. Do not use heat.
4. Create a vortex with the water and gradually add the anhydrous disodium phosphate into the vortex.
5. Add phosphoric acid 85%.
6. QS to final volume with sterile water. Stir well.
7. Transfer to an amber container and label.
8. After 48 hours, Joulie's solution may be filtered through a 0.22-micron filter to increase stability to 6 months.

Notes Joulie's Solution contains 2 mmol sodium/mL and 1.45 mmol phosphate/mL.

pH of Joulie's Solution = 5.9.

Sodium phosphate dibasic [Na2HPO4] is also known as disodium hydrogen phosphate, anhydrous.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Protect From Light
  Store at Room Temperature

Storage/Expiry:Room Temperature: 6 months (filtered)
  Room Temperature: 30 days (unfiltered)

Last Date Revised: 30-May-13

References:IWK Compounding Formulas (online recipes). Halifax, NS: IWK Health Center. Anhydrous Phosphate (Joulie’s) Oral Solution 45 mg/mL - last revised October 14, 2009.

Martindale, 28th edition.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   6-Dec-2021         


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