Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Levetiracetam Oral Suspension   50 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    levetiracetam  500 mg  TAB   
    Ora-Plus® / Ora-Sweet®  1:1  SYRUP  qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. In a mortar, crush tablets and triturate to a fine powder.
2. Mix Ora-Plus® and Ora-Sweet® together (1:1) to make vehicle.
3. Gradually levigate powder with vehicle until a liquid is formed. Stir after each addition.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with vehicle. Mix thoroughly.
6. Transfer to final container and label.

Notes If tablets are difficult to crush:
1. Place tablets in mortar and soak in a small amount of water (approximately 5 mL) for 5 to 10 minutes.
2. Once tablets are sufficiently softened/dissolved, grind tablets to form a smooth paste.
3. Follow remaining steps in the directions section.

Ora-Blend® can be used instead of Ora-Plus®/ Ora-Sweet® (1:1).

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Protect From Light
  Shake Well

Storage/Expiry:Refrigerator or Room Temperature: 91 days

Last Date Revised: 23-Aug-16

References:Ensom MHH, Decarie D, Rudolph S. Stability of Levetiracetam in Extemporaneously Compounded Suspensions. Can J Hosp Pharm 2011;64(3):207-211.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist

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