Recipe - Compounding Worksheet
Unauthorized distribution, copying or disclosure prohibited.
These recipes are intended for use by the pharmacy manufacturing departments only.
Acyclovir Oral Solution   5 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    acyclovir  500 mg  VIAL   
    Water, sterile        
    dextrose in water  5%  INJ   
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: To prepare a 100 mL oral solution:
1. Reconstitute one 500 mg vial with 10 mL of sterile water for injection.
2. Transfer 10 mL of the 50 mg/mL reconstituted solution to an amber bottle and qs to 100 mL with D5W.
3. Mix well.

Notes To be prepared ONLY in the event that the commercial product is NOT available or unsuitable.

Strength of compounded formulation is different than the commercial preparation.
This strength is non-formulary.
Refer to Acyclovir suspension in AHS Provincial Formulary.

Storage in refrigerator preferred to decrease the risk of microbial growth.

Alternatively, the 50 mg/mL injectable vial can be used to prepare a 100 mL oral solution. Transfer 10 mL of the 50 mg/mL solution for injection into an amber bottle and qs to 100 mL with D5W and mix well.

Assign expiry date using USP 795 Guidelines.
795 guidelines: Water-Containing Formulations:
The beyond-use date is not later than 14 days for liquid preparations when stored at cold temperature between 2C - 8C.

THIS FORMULATION IS NOT BASED ON LITERATURE, but is from unpublished data, historical use, or physician/pharmacy experience.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Refrigerate
  Shake Well

Storage/Expiry:Refrigerator: 14 days

Last Date Revised: 24-Jan-14

References:USP 34 NF 29, 2nd Volume 1. Chapter 795: Pharmaceutical compounding Nonsterile preparations. Rockville, MD, USA: United States Pharmacopeial Convention; 2010

Trissel LA. Handbook on injectable drugs. 15th ed. Bethesda MD: American Society of Health-System Pharmacists Inc.; 2009.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   29-Nov-2021         


This content is provided for general information purposes only. It is not intended to replace consultations with a health care professional or to provide medical advice, diagnosis or treatment. Always seek the advice of a physician or other qualified health care provider with any medical or health questions. Alberta Health Services accepts no responsibility for any modification or redistribution of this document and is not liable for any actions taken by individuals based on the information provided, or for any inaccuracies, errors, or omissions in the information in this document. These recipes are to be used as a reference and are not intended to be master formulation records. Not all recipes may be compliant with NAPRA or other standards.