||To prepare a 100 mL oral solution:
1. Reconstitute one 500 mg vial with 10 mL of sterile water for injection.
2. Transfer 10 mL of the 50 mg/mL reconstituted solution to an amber bottle and qs to 100 mL with D5W.
3. Mix well.
||To be prepared ONLY in the event that the commercial product is NOT available or unsuitable.
Strength of compounded formulation is different than the commercial preparation.
This strength is non-formulary.
Refer to Acyclovir suspension in AHS Provincial Formulary.
Storage in refrigerator preferred to decrease the risk of microbial growth.
Alternatively, the 50 mg/mL injectable vial can be used to prepare a 100 mL oral solution. Transfer 10 mL of the 50 mg/mL solution for injection into an amber bottle and qs to 100 mL with D5W and mix well.
Assign expiry date using USP 795 Guidelines.
795 guidelines: Water-Containing Formulations:
The beyond-use date is not later than 14 days for liquid preparations when stored at cold temperature between 2°C - 8°C.
THIS FORMULATION IS NOT BASED ON LITERATURE, but is from unpublished data, historical use, or physician/pharmacy experience.
|| Amber Plastic Bottle
|Storage/Expiry:||Refrigerator: 14 days|
|Last Date Revised:
|References:||USP 34 – NF 29, 2nd Volume 1. Chapter 795: Pharmaceutical compounding – Nonsterile preparations. Rockville, MD, USA: United States Pharmacopeial Convention; 2010 |
Trissel LA. Handbook on injectable drugs. 15th ed. Bethesda MD: American Society of Health-System Pharmacists Inc.; 2009.