||1. Withdraw morphine from ampoules into a syringe using a filter needle. A filter needle is not necessary if using vials.
2. Remove filter needle and transfer morphine to an amber bottle.
3. QS to final volume with sterile water.
||References used morphine chlorhydrate, but morphine sulfate is more readily available and stability is supported by Trissel's Handbook of Injectable Drugs reference.
THIS FORMULATION IS NOT BASED ON LITERATURE, but is from unpublished data, historical use or physician/pharmacy experience.
||100 mL Amber Plastic Bottle
||Store at Room Temperature|
|Storage/Expiry:||Room Temperature: 14 days|
|Last Date Revised:
|References:||Trissel LA. Handbook on injectable drugs. 15th ed. Bethesda MD: American Society of Health-System Pharmacists Inc.; 2009. |
Cerchietti L. Morphine mouthwashes for painful mucositis. Support Care Cancer 2007; 15:115-116.
Cerchietti LCA. Navigante AH. Bonomi MR. Zaderajko MA. Menendez PR. Pogany CE. Roth BM. Effect of topical morphine for mucositis-associated pain following concomitant chemoradiotherapy for head and neck carcinoma. Cancer 2002; 95(10):2230-2236.
Cerchietti LCA. Navigante AH. Korte MW. Cohen AM. Quiroga PN. Villaamil EC. Bonomi MR. Roth BM. Potential utility of the peripheral analgesic properties of morphine in stomatitis-related pain: a pilot study. Pain 2003; 105:265-273.