Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Tranexamic Acid Mouthwash Solution (prepared from injection)   48 mg/mL *Note Strength*
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    tranexamic acid  100 mg/mL  INJ  (ampoules) 
    Water, sterile        
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. Using a 5 micron filter needle, withdraw required amount of tranexamic acid from ampoules into a syringe. Remove filter needle.
2. Measure required amount of sterile water in a separate syringe.
3. Using a syringe tip connector, combine tranexamic acid and sterile water into one syringe. Roll gently to mix
4. Transfer mixture into a final container.

Notes Alternatively, tranexamic acid 100 mg/mL vials can be used instead of ampoules.

THIS FORMULATION IS NOT BASED ON LITERATURE, but is from unpublished data, historical use, or physician/pharmacy experience.
HOWEVER, stability is extrapolated from published literature with stability data for extemporaneously compounded tranexamic acid 50 mg/mL solution. (Lam, 2011)

Packaging:  Amber Glass Bottle

Auxiliary Labels: Note Strength
  Protect From Light

Storage/Expiry:Refrigerator: 5 days

Last Date Revised: 26-Aug-21

References:Lam MS. Extemporaneous compounding of oral liquid dosage formulations and alternative drug delivery methods for anticancer drugs. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 2011 Feb;31(2):164-92. (Regarding stability information, protect from light)

The Hospital for Sick Children, Toronto ON. Email communication from Karen Walsh (compounding pharmacist) to Alberta Children's Hospital on May 7, 2007. (Regarding stability information).

The Hospital for Sick Children, Toronto ON. Faxed communication from Karen Walsh (compounding pharmacist) to Alberta Children's Hospital on August 14, 2000. (Regarding recipe).

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist

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