Recipe - Compounding Worksheet
Unauthorized distribution, copying or disclosure prohibited.
These recipes are intended for use by the pharmacy manufacturing departments only.
Amiodarone Oral Suspension (LOW STRENGTH)   5 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    amiodarone  200 mg  TAB   
    Methylcellulose 1% (preserved with parabens) / Simple Syrup   1:1    qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. In a mortar, crush tablets and triturate to a fine powder.
2. Mix methylcellulose 1% and simple syrup together (1:1) to make vehicle.
3. Gradually levigate powder with vehicle until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with vehicle.
5. Transfer to final container and label.

Notes See recipe for Methylcellulose 1% solution (preserved with parabens).
May substitute Methylcellulose 1% solution (preserved with parabens) with the commercially available Medisca Methylcellulose Gel 1% vehicle for oral liquid preparations.

May substitute Methylcellulose 1% solution (preserved with parabens)/ Simple Syrup 1:1 mixture with any of the following vehicles:
- Ora-Plus® / Ora-Sweet® (1:1)
- Ora-Plus® / Ora-Sweet SF® (1:1)
- Ora-Blend®
- Ora-Blend SF®

- There are reports that the final product becoming granular or separated if Ora-Sweet®/ Ora Plus® 1:1) or Ora-Blend® are used.
- Formulations prepared with alternative vehicles, should be adjusted to a pH of 6 to 7 with sodium bicarbonate 5% solution (5 gram in 100 mL of sterile water).

For best results prepare with Methylcellulose 1% solution (preserved with parabens) and Simple Syrup (1:1) vehicle.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Can be stored at room temperature or refrigerated
  Note Strength
  Shake Well

Storage/Expiry:Refrigerator: 91 days
  Room Temperature: 42 days

Last Date Revised: 12-Mar-19

References:Nahata MC. Stability of amiodarone in an oral suspension stored under refrigeration and at room temperature. Annals of Pharmacotherapy 1997 (Jul/Aug); 31:851-852.

Nahata MC. Morosco RS. Hipple TF. Stability of amiodarone in extemporaneous oral suspensions prepared from commercially available vehicles. The Journal of Pediatric Pharmacy Practice 1999 (July/Aug); 4(4):186-189.

CHEO Non-Sterile Compounds. [online recipes]. Ottawa, ON: Children's Hospital of Eastern Ontario. Http://
Trissel LA. Trissel’s™ Stability of compounded formulations. 4th ed. Washington, DC: American Pharmacists Association; 2009.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist

This content is provided for general information purposes only. It is not intended to replace consultations with a health care professional or to provide medical advice, diagnosis or treatment. Always seek the advice of a physician or other qualified health care provider with any medical or health questions. Alberta Health Services accepts no responsibility for any modification or redistribution of this document and is not liable for any actions taken by individuals based on the information provided, or for any inaccuracies, errors, or omissions in the information in this document. These recipes are to be used as a reference and are not intended to be master formulation records. Not all recipes may be compliant with NAPRA or other standards.