Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Amiodarone Oral Suspension (LOW STRENGTH)   5 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    amiodarone  200 mg  TAB   
    Methylcellulose 1% (preserved with parabens) / Simple Syrup   1:1    qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. In a mortar, crush tablets and triturate to a fine powder.
2. Mix methylcellulose 1% and simple syrup together (1:1) to make vehicle.
3. Gradually levigate powder with vehicle until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with vehicle.
5. Transfer to final container and label.

Notes See recipe for Methylcellulose 1% solution (preserved with parabens).
May substitute Methylcellulose 1% solution (preserved with parabens) with the commercially available Medisca Methylcellulose Gel 1% vehicle for oral liquid preparations.

May substitute Methylcellulose 1% solution (preserved with parabens)/ Simple Syrup 1:1 mixture with any of the following vehicles:
- Ora-Plus® / Ora-Sweet® (1:1)
- Ora-Plus® / Ora-Sweet SF® (1:1)
- Ora-Blend®
- Ora-Blend SF®

- There are reports that the final product becoming granular or separated if Ora-Sweet®/ Ora Plus® 1:1) or Ora-Blend® are used.
- Formulations prepared with alternative vehicles, should be adjusted to a pH of 6 to 7 with sodium bicarbonate 5% solution (5 gram in 100 mL of sterile water).

For best results prepare with Methylcellulose 1% solution (preserved with parabens) and Simple Syrup (1:1) vehicle.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Can be stored at room temperature or refrigerated
  Note Strength
  Shake Well

Storage/Expiry:Refrigerator: 91 days
  Room Temperature: 42 days

Last Date Revised: 12-Mar-19

References:Nahata MC. Stability of amiodarone in an oral suspension stored under refrigeration and at room temperature. Annals of Pharmacotherapy 1997 (Jul/Aug); 31:851-852.

Nahata MC. Morosco RS. Hipple TF. Stability of amiodarone in extemporaneous oral suspensions prepared from commercially available vehicles. The Journal of Pediatric Pharmacy Practice 1999 (July/Aug); 4(4):186-189.

CHEO Non-Sterile Compounds. [online recipes]. Ottawa, ON: Children's Hospital of Eastern Ontario. Http://www.cheo.on.ca/en/healthcareprofessionalsforpharmacists
 
Trissel LA. Trissel’s™ Stability of compounded formulations. 4th ed. Washington, DC: American Pharmacists Association; 2009.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   6-Dec-2021         


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