Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Busulfan Oral Suspension   2 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    busulfan  2 mg  TAB   
    Simple syrup      qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: HAZARDOUS - CYTOTOXIC
Refer to the AHS Hazardous Medication Handling Guide for more information.

1. In a glass mortar, crush tablets and triturate to a fine powder.
2. Gradually levigate powder with simple syrup until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with simple syrup.
6. Transfer to final container and label.

Notes No stability data in plastic syringes.

Packaging:  Amber Glass Bottle

Auxiliary Labels: Antineoplastic Agent
  CHEMOTHERAPY Dispose of Properly
  Cytotoxic
  Hazardous medication - use safe handling precautions
  Protect From Light
  Refrigerate
  Shake Well

Storage/Expiry:Refrigerator: 30 days
  Room Temperature: 3 days

Last Date Revised: 16-May-18

References: AHS Hazardous Medication Handling information available on Insite: http://insite.albertahealthservices.ca/17382.asp

Allen LV. Busulfan oral suspension. U.S. Pharmacist 1990 (Nov); 15(11):94-95.

Formulations: Busulfan 2 mg/mL oral liquid. International Journal of Pharmaceutical Compounding 2007 (Mar/Apr); 11(2):155.

Written communication from Glaxo Wellcome to Alberta Children's Hospital Drug Information Pharmacist; April 22, 1998. Extemporaneous Preparation of a MyleranŽ (Busulfan) Suspension.
 
Nahata MC, Pai VB, Hipple TF. Pediatric drug formulations. 5th ed. Cincinnati, OH: Harvey Whitney Books Company; 2003.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   29-Nov-2021         


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