Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Chlorambucil Oral Suspension   2 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    chlorambucil  2 mg  TAB   
    HSC suspending vehicle       qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: HAZARDOUS - CYTOTOXIC
Refer to the AHS Hazardous Medication Handling Guide for more information.

1. Wet tablets with HSC vehicle in a mortar and grind to a paste.
2. Gradually levigate with HSC vehicle until a liquid has formed.
3. Pour into a graduated cylinder.
4. Rinse mortar and qs to final volume.
5. Transfer to final container and label.

Notes See recipe for HSC Suspending vehicle.

NOTE:
The original recipe used Methylcellulose 1%/ Simple Syrup in a 1:1 ratio. An arbitrary decision was made to substitute HSC vehicle (Methylcellulose 1%/ Simple Syrup in a 2.33:1 ratio) for this recipe.

May substitute HSC vehicle with Methylcellulose 1% (preserved with parabens)/ Simple Syrup in 1:1 ratio.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Antineoplastic Agent
  CHEMOTHERAPY Dispose of Properly
  Cytotoxic
  Hazardous medication - use safe handling precautions
  Protect From Light
  Refrigerate
  Shake Well

Storage/Expiry:Refrigerator: 7 days

Last Date Revised: 15-Dec-20

References:AHS Hazardous Medication Handling information available on Insite: http://insite.albertahealthservices.ca/17382.asp

Dressman JB. Poust RI. Stability of allopurinol and 5 antineoplastics in suspension. Am J Hosp Pharm 1983; 40:616-618.
 
Nahata MC, Pai VB, Hipple TF. Pediatric drug formulations. 5th ed. Cincinnati, OH: Harvey Whitney Books Company; 2003.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   29-Nov-2021         


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