Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Atenolol Oral Suspension   2 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    atenolol  50 mg  TAB   
    glycerin  100%  PO SOLN   
    Ora-Sweet® Sugar Free    SYRUP  qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. In a mortar, crush tablets and triturate to a fine powder.
2. Levigate powder with glycerin to form a paste.
3. Gradually add vehicle until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with vehicle.
6. Transfer to final container and label.

Notes For a more uniform suspension, place tablets in mortar and soak in a small amount of water (approximately 2 to 3 mL) for 5 to 10 minutes. Follow remaining steps in Directions section.

Simple Syrup can be used instead of Ora-Sweet SF®.

Ora-Sweet SF® should not be used in neonates less than or equal to 28 days corrected age.

Stability of the formulation will depend on the suspending vehicle used (see Storage/Expiry section).

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Refrigerate
  Shake Well

Storage/Expiry:Refrigerator: 14 days (with Simple Syrup)
  Refrigerator: 90 days (with Ora-Sweet SF®)

Last Date Revised: 23-Oct-17

References:Patel D, Doshi DH, Desai A. Short-term stability of atenolol in oral liquid formulations. International Journal of Pharmaceutical Compounding 1997; 1:437-439.
 
Nahata MC, Pai VB, Hipple TF. Pediatric drug formulations. 5th ed. Cincinnati, OH: Harvey Whitney Books Company; 2003.
 
Nahata MC, Pai VB, Hipple TF. Pediatric drug formulations. 5th ed. Cincinnati, OH: Harvey Whitney Books Company; 2003.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   29-Nov-2021         


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