Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Levodopa/ Carbidopa Rectal Suspension    100 mg-25 mg/mL *Note Strength*
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    levodopa - carbidopa  100 mg - 25 mg  TAB   
    Water, sterile        
    glycerin  100%  PO SOLN   
    Citric acid, anhydrous USP    PWD   
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. In a mortar, crush tablets and triturate to a fine powder.
2. Mix water and glycerin together (1:1) to make vehicle.
3. Combine citric acid and levodopa-carbidopa powder.
4. Gradually levigate powder mixture with vehicle until uniform.
5. Transfer to final container and label.

Notes Administer levodopa-carbidopa suspension (1 tablet per mL) using a 3 mL syringe attached to a 6 cm catheter.

Do not use controlled release tablets to prepare recipe.

Citric acid is added to lower pH to 2.3 to 2.4.

Can use levodopa-carbidopa 250 mg/25 mg tablets if patient requires higher dose; NOTE this will provide a different strength of the formulation.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Note Strength
  Protect From Light
  Refrigerate
  Shake Well

Storage/Expiry:Refrigerator: Less than 24 hours (stability of preparation is uncertain)

Last Date Revised: 18-Oct-21

References:Cooper SD. Ismail HA. Frank C. Canadian Family Physician 2001; 47:112-113.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   6-Dec-2021         


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