Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Cholestyramine Resin in Ihle's Paste    20%
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    cholestyramine  4 g  PKT  8 grams resin /18 grams powder 
    Ihle's Paste     UNG   
Recipe Total Quantity:
Final Quantity Desired: g

Directions: 1. Triturate cholestyramine to a fine powder to ensure a non-gritty preparation.
2. Gradually levigate powder into Ihle's paste until smooth.
3. Transfer to ointment jar and label.

Notes NOTE:
Cholestyramine resin 8 grams = cholestyramine 18 grams powder = 2 packets

Assign expiry date using USP 795 Guidelines, since no stability data available.
USP 795 guidelines - Solid Formulations:
"Where the manufactured drug product is the active ingredient source - not later than 25% of the time remaining until the preparation expiration date or 6 months, whichever is earlier.
Where USP or NF is the active ingredient source - 6 months"

THIS FORMULATION IS NOT BASED ON LITERATURE, but is from unpublished data, historical use, or physician/pharmacy experience.

Packaging:  Ointment Jar

Auxiliary Labels: For External Use Only
  Store at Room Temperature

Storage/Expiry:Room Temperature: 6 months

Last Date Revised: 24-Jan-14

References:IWK Grace Health Centre for Children, Women and Families Pharmacy Department. Pocket Book of Extemporaneous Formulation 1999. First Edition. Halifax, Nova Scotia.
The recipe is based on the formulation from this reference, which used 8 grams of cholestyramine resin in 22 grams of zinc oxide 20% ointment, but assigned a 1 year room temperature expiry.
 
USP 34 NF 29, 2nd Volume 1. Chapter 795: Pharmaceutical compounding Nonsterile preparations. Rockville, MD, USA: United States Pharmacopeial Convention; 2010

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   29-Nov-2021         


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