||1. Triturate cholestyramine to a fine powder to ensure a non-gritty preparation.
2. Gradually levigate powder into Ihle's paste until smooth.
3. Transfer to ointment jar and label.
Cholestyramine resin 8 grams = cholestyramine 18 grams powder = 2 packets
Assign expiry date using USP 795 Guidelines, since no stability data available.
USP 795 guidelines - Solid Formulations:
"Where the manufactured drug product is the active ingredient source - not later than 25% of the time remaining until the preparation expiration date or 6 months, whichever is earlier.
Where USP or NF is the active ingredient source - 6 months"
THIS FORMULATION IS NOT BASED ON LITERATURE, but is from unpublished data, historical use, or physician/pharmacy experience.
|| Ointment Jar
||For External Use Only|
||Store at Room Temperature
|Storage/Expiry:||Room Temperature: 6 months|
|Last Date Revised:
|References:||IWK Grace Health Centre for Children, Women and Families Pharmacy Department. Pocket Book of Extemporaneous Formulation 1999. First Edition. Halifax, Nova Scotia.|
The recipe is based on the formulation from this reference, which used 8 grams of cholestyramine resin in 22 grams of zinc oxide 20% ointment, but assigned a 1 year room temperature expiry.
USP 34 – NF 29, 2nd Volume 1. Chapter 795: Pharmaceutical compounding – Nonsterile preparations. Rockville, MD, USA: United States Pharmacopeial Convention; 2010