||1. In a mortar, crush tablets and triturate to a fine powder.
2. Gradually levigate powder with simple syrup until a liquid is formed.
3. Pour into a graduated cylinder.
4. Rinse mortar and qs to final volume with simple syrup.
5. Transfer to final container and label.
||References determined stability of suspension stored in glass bottles.
The use of syrup as a vehicle for captopril oral suspension is not recommended. It has poor suspending capabilities with regards to insoluble tablet excipients, some of which may bind to the active drug. Therefore, dose uniformity is a concern.
||(see Notes section) Amber Glass Bottle
|Storage/Expiry:||Refrigerator: 30 days|
|Last Date Revised:
|References:||Lye M, Yow KL, Lim LY, Chan SY, Chan E and HO PC. Effects of ingredients on stability of captopril in extemporaneously prepared oral liquids. Am J Health-Syst Pharm 1997; 54:2483-2487.|
Walsh K. Book review: Children’s Hospital of Philadelphia Extemporaneous Formulations. Can J Hosp Pharm 2004 (Feb); 57(1):42-43.
Jackson M. Handbook of extemporaneous preparation: a guide to pharmaceutical compounding. London; Chicago: Pharmaceutical Press; 2010
Lowey A and Jackson M. How to ensure the quality and safety of unlicensed oral medicines. The Pharmaceutical Journal 2008; 281:240.
Trissel LA. Trissel’s™ Stability of compounded formulations. 4th ed. Washington, DC: American Pharmacists Association; 2009.