Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Beclomethasone Dipropionate Oral Suspension    1 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    beclomethasone dipropionate micronized, USP    PWD   
    Corn oil    OIL  qs to  
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. Weigh required amount of beclomethasone powder and place in mortar.
2. Gradually levigate corn oil into the beclomethasone powder until a liquid is formed.
3. Pour into a graduated cylinder.
4. Rinse mortar and qs to final volume with corn oil.
5. Transfer to final container and label.

Notes Since no stability data available, use beyond use date from original recipe, which is more conservative than the NAPRA BUD. Consensus reached with CNR for 90 day room temperature BUD.

Note: this recipe is NOT water-containing.
THIS FORMULATION IS NOT BASED ON LITERATURE, but is from unpublished data, historical use, or physician/pharmacy experience.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Shake Well
  Store at Room Temperature

Storage/Expiry:Room Temperature: 90 days

Last Date Revised: 7-Sep-21

References:AHS Drug Information Service. Previous Question #20727: What should the BUD be for beclomethasone dipropionate oral suspension 1 mg/mL? 2021 Sept 7. Available at https://webappsint.albertahealthservices.ca/Pharmacy/PS_DI/admin_user/view_request.aspx?id=20727

Swick A. Beclomethasone Oral. Nationwide Children's Compounding Formulas [online]. Columbus, OH: Nationwide Children's Hospital; 2020. Accessed: 2021-09-07. Available from: https://www.nationwidechildrens.org/specialties/pharmacy-services/compounding-formulas

Fred Hutchison Cancer Centre; Seattle, WA. USA.

Iyer RV. Hahn T. Roy HN. Battiwalla M. Cooper M. Anderson B. Paplham P. Brown K. Bambach B. Segal BH. McCarby Jr. PL. Long-term use of oral beclomethasone dipropionate for the treatment of gastrointestinal graft-versus-host disease. Biol Blood Marrow Transplant 2005; 11: 587-92.

Miura Y. Narimatsu H. Kami M. Kusumi E. Matsumura T. Yuji K. Wake A. Miyakoshi S. Taniguchi S. Oral beclomethasone dipropionate as an initial treatment of gastrointestinal acute graft-versus-host disease after reduced-intensity cord blood transplantation. Bone Marrow Transplantation 2006; 38: 577-579.
 
National Association of Pharmacy Regulatory Authorities (NAPRA). Guidance Document For Pharmacy Compounding Of Non-Sterile Preparations. Ottawa, ON: National Association of Pharmacy Regulatory Authorities (NAPRA); 2018.
Available at: https://napra.ca/sites/default/files/documents/Mdl_Stnds_Pharmacy_Compounding_Nonsterile_Preparations_Guidance_June2018_FINAL.pdf
 
National Association of Pharmacy Regulatory Authorities (NAPRA). Guidance Document For Pharmacy Compounding Of Non-Sterile Preparations. Ottawa, ON: National Association of Pharmacy Regulatory Authorities (NAPRA); 2018.
Available at: https://napra.ca/sites/default/files/documents/Mdl_Stnds_Pharmacy_Compounding_Nonsterile_Preparations_Guidance_June2018_FINAL.pdf

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   29-Nov-2021         


This content is provided for general information purposes only. It is not intended to replace consultations with a health care professional or to provide medical advice, diagnosis or treatment. Always seek the advice of a physician or other qualified health care provider with any medical or health questions. Alberta Health Services accepts no responsibility for any modification or redistribution of this document and is not liable for any actions taken by individuals based on the information provided, or for any inaccuracies, errors, or omissions in the information in this document. These recipes are to be used as a reference and are not intended to be master formulation records. Not all recipes may be compliant with NAPRA or other standards.