Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
L-Arginine Base Oral Solution   100 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    l-arginine USP    PWD   
    Citric acid, anhydrous USP    PWD   
    Water, sterile       qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. Wearing gloves and a mask, weigh out l-arginine and citric acid powders.
2. Dissolve powders in water and qs to final volume.
3. Transfer to final container and label.

Notes This formulation is recommended for ORAL use in Urea Cycle Disorders consult Metabolic Specialist or Metabolic Protocols.
The l-arginine hydrochloride recipe can be used, but for short-term ORAL use only (see recipe in AHS Recipe Database).

Citric acid anhydrous can be substituted with citric acid monohydrate.
Citric acid anhydrous 18.15 g = citric acid monohydrate 19.85 g.

This formulation is NOT RECOMMENDED in metabolic alkalosis patients, and in neonates with resistant hypochloremia or necrotizing enterocolitis; L-arginine hydrochloride recipe is preferred (see recipe in AHS Recipe Database).

Since no stability data available, assign beyond use date using NAPRA Guidance Document For Pharmacy Compounding Of Non-Sterile Preparations:
For Water Containing Oral Formulations: The BUD is not later than 14 days when stored at controlled cold temperatures.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Refrigerate

Storage/Expiry:Refrigerator: 14 days

Last Date Revised: 24-Aug-21

References:MSDS sheet for l-arginine USP powder.
  Modified original 200 mg/mL recipe to prepare a 100 mg/mL solution by adding citric acid powder to adjust the pH to 7.3 - 7.5, since the original recipe was too alkaline (pH of 11.49).

McCrea J, Rappaport P, Stansfield S, Baker D, Dupuis LL. James G., Extemporaneous oral liquid dosage preparations. 1st ed. Toronto, ON: Canadian Society of Hospital Pharmacists; 1988.
  For Water Containing Oral Formulations: The BUD is not later than 14 days when stored at controlled cold temperatures.
McCrea J, Rappaport P, Stansfield S, Baker D, Dupuis LL. James G., Extemporaneous oral liquid dosage preparations. 1st ed. Toronto, ON: Canadian Society of Hospital Pharmacists; 1988.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   6-Dec-2021         


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