Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
metroNIDAZOLE Benzoate Oral Suspension   50 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    metronidazole benzoate    PWD   
    Ora-Plus® / Ora-Sweet®  1:1  SYRUP  qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. Weigh out metronidazole benzoate powder and place in mortar.
2. Mix Ora-Plus® and Ora-Sweet® together (1:1) to make vehicle.
3. Gradually levigate powder with vehicle until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with vehicle.
6. Transfer to final container and label.

Notes Metronidazole benzoate powder has a bland taste and is more palatable compared to the bitter taste of metronidazole base.

NOTE:
Metronidazole benzoate is not equivalent to metronidazole base on a dose basis:
conversion = 0.625
(i.e. 200 mg metronidazole benzoate = 125 mg metronidazole base)

May substitute Ora-Plus® / Ora-Sweet® (1:1) with any of the following vehicles:
- Ora-Plus® / Ora-Sweet SF® (1:1)
- Ora-Blend®
- Ora-Blend SF®

Ora-Sweet SF® and Ora-Blend SF® should not be used in neonates less than or equal to 28 days corrected age.

This recipe is based on information extrapolated from the literature:
- Metronidazole 50 mg/mL oral suspension prepared from metronidazole powder in Ora-Plus®/ Ora-Sweet® (1:1) or Ora-Plus®/ Ora-Sweet SF® (1:1), with a stability of 60 days at room temperature or refrigerated (see AJHP reference).

THIS FORMULATION IS NOT BASED ON LITERATURE, but is from unpublished data, historical use, or physician/pharmacy experience.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Protect From Light
  Refrigerate
  Shake Well

Storage/Expiry:Refrigerator or Room Temperature: 60 days (refrigerated storage preferred)

Last Date Revised: 25-Jul-14

References:Allen LV, Erickson MA. Stability of ketoconazole, metolazone, metronidazole, procainamide hydrochloride, and spironolactone in extemporaneously compounded oral liquids. Am J Health-Syst Pharm 1996 (Sept 1); 53:2073-2078.
Metronidazole 50 mg/mL oral suspension prepared from metronidazole powder in Ora-Plus®/ Ora-Sweet® (1:1) or Ora-Plus®/ Ora-Sweet SF® (1:1), with a stability of 60 days at room temperature or refrigerated.

Mathew M, Das Gupta V, Bethea C. Stability of metronidazole benzoate in suspensions. J Clin Pharm Ther 1994; 19:31-34.
Metronidazole benzoate 16 mg/mL oral suspension prepared from metronidazole benzoate powder in Ora-Plus® or Ora-Plus®/ Ora-Sweet® (1:1) with a stability of 90 days at room temperature.
 
Nahata MC, Pai VB, Hipple TF. Pediatric drug formulations. 5th ed. Cincinnati, OH: Harvey Whitney Books Company; 2003.
 
Nahata MC, Pai VB, Hipple TF. Pediatric drug formulations. 5th ed. Cincinnati, OH: Harvey Whitney Books Company; 2003.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   6-Dec-2021         


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