||1. In a mortar, crush tablets and triturate to a fine powder.
2. Levigate powder with glycerin to form a paste.
3. Gradually add simple syrup until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with simple syrup.
6. Transfer to final container and label.
||Cimetidine tablets are Non-Formulary with a Therapeutic Interchange.
Refer to Therapeutic Interchange List Section 56:00 Gastrointestinal Drugs Non-formulary Oral Histamine H2- Antagonists.
May allow tablets to stand in 5 mL of water for 3 to 5 minutes to allow film coating to dissolve prior to preparing paste with glycerin.
|| Amber Plastic Bottle
|Storage/Expiry:||Refrigerator: 17 days|
|Last Date Revised:
|References:||Tortorici MP. Formulation of a cimetidine oral suspension. American Journal of Hospital Pharmacy 1979; 36:22.|
Sparkman HE. Experience with cimetidine oral suspension formulation. American Journal of Hospital Pharmacy 1979; 36:600.
Formulations. Cimetidine 60 mg/mL oral liquid, alcohol free. International Journal of Pharmaceutical Compounding 2006; 10(2):139.
Nahata MC, Pai VB. Pediatric drug formulations. 6th ed. Cincinnati, Ohio: Harvey Whitney Books Company; 2011.