Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Cimetidine Oral Suspension    60 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    cimetidine  300 mg  TAB   
    glycerin  100%  PO SOLN   
    Simple syrup       qs to  
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. In a mortar, crush tablets and triturate to a fine powder.
2. Levigate powder with glycerin to form a paste.
3. Gradually add simple syrup until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with simple syrup.
6. Transfer to final container and label.

Notes Cimetidine tablets are Non-Formulary with a Therapeutic Interchange.
Refer to Therapeutic Interchange List Section 56:00 Gastrointestinal Drugs Non-formulary Oral Histamine H2- Antagonists.

May allow tablets to stand in 5 mL of water for 3 to 5 minutes to allow film coating to dissolve prior to preparing paste with glycerin.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Refrigerate
  Shake Well

Storage/Expiry:Refrigerator: 17 days

Last Date Revised: 15-Mar-18

References:Tortorici MP. Formulation of a cimetidine oral suspension. American Journal of Hospital Pharmacy 1979; 36:22.

Sparkman HE. Experience with cimetidine oral suspension formulation. American Journal of Hospital Pharmacy 1979; 36:600.

Formulations. Cimetidine 60 mg/mL oral liquid, alcohol free. International Journal of Pharmaceutical Compounding 2006; 10(2):139.
 
Nahata MC, Pai VB. Pediatric drug formulations. 6th ed. Cincinnati, Ohio: Harvey Whitney Books Company; 2011.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   29-Nov-2021         


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