Recipe - Compounding Worksheet
Unauthorized distribution, copying or disclosure prohibited.
These recipes are intended for use by the pharmacy manufacturing departments only.
Cimetidine Oral Suspension    60 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    cimetidine  300 mg  TAB   
    glycerin  100%  PO SOLN   
    Simple syrup       qs to  
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. In a mortar, crush tablets and triturate to a fine powder.
2. Levigate powder with glycerin to form a paste.
3. Gradually add simple syrup until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with simple syrup.
6. Transfer to final container and label.

Notes Cimetidine tablets are Non-Formulary with a Therapeutic Interchange.
Refer to Therapeutic Interchange List Section 56:00 Gastrointestinal Drugs Non-formulary Oral Histamine H2- Antagonists.

May allow tablets to stand in 5 mL of water for 3 to 5 minutes to allow film coating to dissolve prior to preparing paste with glycerin.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Refrigerate
  Shake Well

Storage/Expiry:Refrigerator: 17 days

Last Date Revised: 15-Mar-18

References:Tortorici MP. Formulation of a cimetidine oral suspension. American Journal of Hospital Pharmacy 1979; 36:22.

Sparkman HE. Experience with cimetidine oral suspension formulation. American Journal of Hospital Pharmacy 1979; 36:600.

Formulations. Cimetidine 60 mg/mL oral liquid, alcohol free. International Journal of Pharmaceutical Compounding 2006; 10(2):139.
Nahata MC, Pai VB. Pediatric drug formulations. 6th ed. Cincinnati, Ohio: Harvey Whitney Books Company; 2011.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist

This content is provided for general information purposes only. It is not intended to replace consultations with a health care professional or to provide medical advice, diagnosis or treatment. Always seek the advice of a physician or other qualified health care provider with any medical or health questions. Alberta Health Services accepts no responsibility for any modification or redistribution of this document and is not liable for any actions taken by individuals based on the information provided, or for any inaccuracies, errors, or omissions in the information in this document. These recipes are to be used as a reference and are not intended to be master formulation records. Not all recipes may be compliant with NAPRA or other standards.