||HAZARDOUS - REPRODUCTIVE
Refer to the AHS Hazardous Medication Handling Guide for more information.
1. In a mortar, crush tablets and triturate to a fine powder.
2. Add approximately 10 mL of vehicle to make a paste.
3. Gradually levigate paste with vehicle until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with vehicle.
6. Transfer to final container and label.
|| Amber Plastic or Glass Bottle
||Can be stored at room temperature or refrigerated|
||Protect From Light
|Storage/Expiry:||Refrigerator or Room Temperature: 91 days|
|Last Date Revised:
|References:||Ziegler BE, Walsh A, Walker SE, Law S, Lingertat-Walsh K, Sales P. Stability of Clobazam 1mg/mL in Extemporaneously Compounded Oral Suspensions Using Oral Mix Vehicle in PET, PVC, Glass Bottles and Plastic Unit-Dose Syringes. Can J Hosp Pharm. 2014 Jan-Feb;67(1):70. |
Available from: https://www.cjhp-online.ca/index.php/cjhp/article/view/1325/1862
Also available from: https://www.medisca.com/Pages/Studies/pdf-files/publications/oral/Extemporaneously%20compounded%20Clobazam%201mg-mL%20Poster.pdf
||No formal stability study conducted of clobazam suspension prepared with Ora-Blend or Ora-Plus or other commercial bases.
Recipe is a suggested option.
Woods DJ. Formulation in pharmacy practice. 2nd edition, Dunedin, New Zealand. Available from: