Recipe - Compounding Worksheet
Unauthorized distribution, copying or disclosure prohibited.
These recipes are intended for use by the pharmacy manufacturing departments only.
hydrALAzine Oral Suspension (prepared from injection)   4 mg/mL *Note Strength*
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    hydralazine   20 mg/mL  INJ   
    Propylene glycol liquid       
    Water, sterile       qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. Withdraw required amount of hydralazine from vials and transfer to a graduated cylinder. Contact with metal parts (e.g. stainless steel syringe needles) should be minimized or avoided if possible. A cannula can be used to draw up the injectable solution from vials.
2. Add propylene glycol.
3. QS to final volume with water.
4. Transfer to final container and label.

Notes If prepared from hydralazine ampoules:
1. Reconstitute each hydralazine ampoule with approximately 1 mL of sterile water that has been drawn up into a syringe WITHOUT any needle.
2. Using a filter straw (do not use any type of metal needle), withdraw the hydralazine, remove filter straw and pour into a graduated cylinder.
3. Add propylene glycol.
4. QS to final volume with water.

NOT FOR USE in neonates less than or equal to 28 days corrected age.
For neonates greater than 28 days, check with physician regarding propylene glycol component.

Make sure all glassware is clean and dry.

DO NOT mix with sugar based syrups as they reduce stability drastically.

Packaging:  Amber Glass Bottle

Auxiliary Labels: Note Strength
  Refrigerate

Storage/Expiry:Refrigerator: 30 days

Last Date Revised: 18-Jul-18

References:Nahata MC, Hipple TH. Pediatric drug formulations. 3rd ed. Cincinnati, Ohio: Harvey Whitney Books Company; 1990.

Lexi-Comp [database on the internet]- Trissel's IV-Chek. Hudson, OH: Lexi-Comp Inc. c.1978 - 2018.

Trissel LA. Handbook on Injectable Drugs, 17th ed. Bethesda, MD: American Society of Health-System Pharmacists, Inc., 2013. Cited date: 17-Jul-2018

Enderlin G. Discoloration of Hydralazine Injection. AJHP 1984 Volume 41: 634.


Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   6-Dec-2021         


This content is provided for general information purposes only. It is not intended to replace consultations with a health care professional or to provide medical advice, diagnosis or treatment. Always seek the advice of a physician or other qualified health care provider with any medical or health questions. Alberta Health Services accepts no responsibility for any modification or redistribution of this document and is not liable for any actions taken by individuals based on the information provided, or for any inaccuracies, errors, or omissions in the information in this document. These recipes are to be used as a reference and are not intended to be master formulation records. Not all recipes may be compliant with NAPRA or other standards.