Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
cloZAPine Oral Suspension   20 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    clozapine  100 mg  TAB   
    Ora-Plus® / Ora-Sweet®  1:1  SYRUP  qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. In a mortar, crush tablets and triturate to a fine powder.
2. Mix Ora-Plus® and Ora-Sweet® together (1:1) to make vehicle.
3. Gradually levigate powder with vehicle until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with vehicle.
6. Transfer to final container and label.

Notes Clozapine tablets are Formulary Restricted.
Refer to Clozapine tablets in AHS Provincial Formulary.

May substitute Ora-Plus® / Ora-Sweet® (1:1) with any of the following vehicles:
- Ora Plus®
- Ora Sweet®
- Ora-Blend®
- HSC Suspending Vehicle
- Simple Syrup

Ensure suspension is prepared using the same brand of clozapine tablets that the patient has been prescribed. Brands are not interchangeable.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Shake Well
  Store at Room Temperature

Storage/Expiry:Room Temperature: 63 days

Last Date Revised: 18-Aug-16

References:Walker SE, Baker D & Law S. Stability of clozapine stored in oral suspension vehicles at room temperature. Can J Hosp Pharm 2005; 58(5):279-284.

Formulations: Clozapine 20-mg/mL oral suspension. International Journal of Pharmaceutical Compounding 2010; 14(3):243.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist

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