Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Cyclophosphamide Oral Suspension   10 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    cyclophosphamide   1000 mg  INJ  1 vial 
    sodium chloride  0.9%  INJ   
    Simple syrup        
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: Refer to the AHS Hazardous Medication Handling Guide for more information.

1. Reconstitute each cyclophosphamide 1 gram (1000 mg) vial with 50 mL of sodium chloride 0.9%.
2. Pour into a graduated cylinder and mix 1:1 with simple syrup.
3. Transfer to final container and label appropriately.

Notes Ora-PlusŪ can be used instead of Simple Syrup, but stability is different at room temperature (see Stability/Expiry section).

Can be stored in polypropylene amber oral bottles or syringes for 56 days refrigerated.

Packaging:  Amber Glass Bottle

Auxiliary Labels: Antineoplastic Agent
  CHEMOTHERAPY Dispose of Properly
  Can be stored at room temperature or refrigerated
  Hazardous medication - use safe handling precautions
  Protect From Light

Storage/Expiry:Refrigerator: 56 days (with Simple Syrup or Ora-PlusŪ)
  Room Temperature: 8 days (with Simple Syrup)
  Room Temperature: 3 days (with Ora-PlusŪ)

Last Date Revised: 14-Dec-20

References: AHS Hazardous Medication Handling information available on Insite:

Kennedy R. Groepper D. Tagen M. Christensen R. Navid F. Gajjar A. Stewart CF. Stability of cyclophosphamide in extemporaneous oral suspensions. Annals of Pharmacotherapy 2010; 44:295-301.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist

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