||1. Wearing gloves and a mask, weigh out l-arginine hydrochloride powder and transfer to a graduated cylinder.
2. QS to final volume with preserved water. Stir well until dissolved (this may take about 5 to 15 minutes).
3. Transfer to final container and label.
||This formulation is recommended for ORAL use in metabolic alkalosis patients and in neonates with resistant hypochloremia or necrotizing enterocolitis.
Although this recipe can be used for short-term ORAL use, it is NOT recommended in patients with Urea Cycle Disorders, l-arginine BASE recipe is preferred (see recipe in AHS Recipe Database).
This recipe should only be compounded instead of the recipe prepared from injection whenever there is a limited supply/shortage of l-arginine hydrochloride injectable.
Since no stability data available, assign beyond use date using NAPRA Guidance Document For Pharmacy Compounding Of Non-Sterile Preparations:
For Water Containing Oral Formulations: The BUD is not later than 14 days when stored at controlled cold temperatures.
THIS FORMULATION IS NOT BASED ON LITERATURE, but is from unpublished data, historical use or physician/pharmacy experience.
|| Amber Plastic Bottle
|Storage/Expiry:||Refrigerator: 14 days|
|Last Date Revised:
|References:||SickKids Compounding Service. Toronto, ON: The Hospital for Sick Children. L-arginine 163 mg/mL (l-arginine HCl 100 mg/mL and l-arginine base 80 mg/mL) oral solution recipe, May 2006. Faxed recipe on file AHS Drug Information. |
Modified recipe to prepare a formulation without l-arginine base.
MSDS sheet from Galenova for l-arginine HCl powder, May 31 2010.
||For Water Containing Oral Formulations: The BUD is not later than 14 days when stored at controlled cold temperatures.
National Association of Pharmacy Regulatory Authorities (NAPRA). Guidance Document For Pharmacy Compounding Of Non-Sterile Preparations. Ottawa, ON: National Association of Pharmacy Regulatory Authorities (NAPRA); 2018.
Available at: https://napra.ca/sites/default/files/documents/Mdl_Stnds_Pharmacy_Compounding_Nonsterile_Preparations_Guidance_June2018_FINAL.pdf