Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
L-Arginine Hydrochloride Oral Solution (prepared from powder)   100 mg/mL (0.475 mmol/mL of chloride)
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    l-arginine hydrochloride USP    PWD   
    Water with sodium benzoate (Preserved Water)   0.1%    qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. Wearing gloves and a mask, weigh out l-arginine hydrochloride powder and transfer to a graduated cylinder.
2. QS to final volume with preserved water. Stir well until dissolved (this may take about 5 to 15 minutes).
3. Transfer to final container and label.

Notes This formulation is recommended for ORAL use in metabolic alkalosis patients and in neonates with resistant hypochloremia or necrotizing enterocolitis.

Although this recipe can be used for short-term ORAL use, it is NOT recommended in patients with Urea Cycle Disorders, l-arginine BASE recipe is preferred (see recipe in AHS Recipe Database).

This recipe should only be compounded instead of the recipe prepared from injection whenever there is a limited supply/shortage of l-arginine hydrochloride injectable.

Since no stability data available, assign beyond use date using NAPRA Guidance Document For Pharmacy Compounding Of Non-Sterile Preparations:
For Water Containing Oral Formulations: The BUD is not later than 14 days when stored at controlled cold temperatures.

THIS FORMULATION IS NOT BASED ON LITERATURE, but is from unpublished data, historical use or physician/pharmacy experience.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Refrigerate

Storage/Expiry:Refrigerator: 14 days

Last Date Revised: 24-Aug-21

References:SickKids Compounding Service. Toronto, ON: The Hospital for Sick Children. L-arginine 163 mg/mL (l-arginine HCl 100 mg/mL and l-arginine base 80 mg/mL) oral solution recipe, May 2006. Faxed recipe on file AHS Drug Information.
Modified recipe to prepare a formulation without l-arginine base.

MSDS sheet from Galenova for l-arginine HCl powder, May 31 2010.
  For Water Containing Oral Formulations: The BUD is not later than 14 days when stored at controlled cold temperatures.
National Association of Pharmacy Regulatory Authorities (NAPRA). Guidance Document For Pharmacy Compounding Of Non-Sterile Preparations. Ottawa, ON: National Association of Pharmacy Regulatory Authorities (NAPRA); 2018.
Available at: https://napra.ca/sites/default/files/documents/Mdl_Stnds_Pharmacy_Compounding_Nonsterile_Preparations_Guidance_June2018_FINAL.pdf

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   6-Dec-2021         


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