Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Dexamethasone Sodium Phosphate Oral Solution in Normal Saline   1 mg/mL (Note Strength)
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    dexamethasone sodium phosphate  10 mg/mL  VIAL  (preservative free vial) 
    sodium chloride (bacteriostatic)  0.9%  INJ   
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. Withdraw required amount of dexamethasone and transfer to a graduated cylinder.
2. QS to final volume with bacteriostatic sodium chloride 0.9%.
3. Mix well.
4. Transfer to final container and label.

Notes This recipe is preferred for neonates corrected age 28 days or less and patients on ketogenic diet.

Use preservative free (without benzyl alcohol) injectable dexamethasone to prepare recipe.

Can substitute dexamethasone sodium phosphate powder USP or dexamethasone tablets for injectable dexamethasone. An arbitrary expiration date of 14 days refrigerated can be assigned based on USP 795 guidelines.

Packaging:  Amber Glass Bottle

Auxiliary Labels: Can be stored at room temperature or refrigerated
  Note Strength

Storage/Expiry:Refrigerator: 14 days (prepared from powder)
  Refrigerator or Room Temperature: 28 days (prepared from injectable solution)

Last Date Revised: 28-Nov-17

References:Lugo RA, Nahata MC. Stability of diluted dexamethasone sodium phosphate injection at two temperatures. Annals of Pharmacotherapy 1994; 28:1018-1019.

July 2014: Recipe changed to injectable dexamethasone 10 mg/mL preservative free product (without benzyl alcohol). References used Sandoz brand of dexamethasone 4 mg/mL injection with metabisulfite and propylparabens as preservatives, which is no longer available. Current Omega brand of dexamethasone 4 mg/mL injection contains benzyl alcohol as a preservative.
Nahata MC, Pai VB, Hipple TF. Pediatric drug formulations. 5th ed. Cincinnati, OH: Harvey Whitney Books Company; 2003.
Nahata MC, Pai VB, Hipple TF. Pediatric drug formulations. 5th ed. Cincinnati, OH: Harvey Whitney Books Company; 2003.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist

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