Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Pyrimethamine Oral Suspension (prepared from powder)   2 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    pyrimethamine, USP     PWD   
    Simple syrup       
    Methylcellulose (preserved with parabens)  1%  PO SOLN   
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. Weigh pyrimethamine USP powder.
2. In a mortar, mix methylcellulose and simple syrup together (1:1) to make vehicle.
3. Gradually levigate pyrimethamine USP powder with vehicle until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with vehicle.
6. Transfer to final container and label.

Notes References used pyrimethamine tablets to prepare recipe, which have been discontinued. Arbitrarily substituted recipe to use pyrimethamine USP powder.

Expiry date assigned based on USP 795 guidelines for Pharmaceutical Compounding - Nonsterile Preparations. No stability studies have been completed with pyrimethamine USP powder.

HSC Suspending vehicle can be used instead of Methylcellulose 1% (preserved with parabens) and Simple Syrup.

Packaging: 100 mL Amber Plastic Bottle

Auxiliary Labels: Shake Well
  Store at Room Temperature

Storage/Expiry:Room Temperature: 30 days

Last Date Revised: 9-Jan-15

References:USP 34 NF 29, 2nd Volume 1. Chapter 795: Pharmaceutical compounding Non-sterile preparations. Rockville, MD, USA: United States Pharmacopeial Convention; 2014

Nahata MC, Pai VB, Hipple TF. Pediatric drug formulations. 5th ed. Cincinnati, OH: Harvey Whitney Books Company; 2003.

SickKids Compounding Service [online recipes]. Toronto, ON: The Hospital for Sick Children. c1999 [current date]. Available from: Pyrimethamine 2 mg/mL oral suspension recipe (last updated April 2007).
Tablets used to prepare recipe, and assigned a stability of 60 days at room temperature with HSC Suspending vehicle.

Nahata MC. Morosco RS. Hipple TF. Stability of pyrimethamine in a liquid dosage formulation stored for three months. Am J Health-Syst Pharm. 1997; 54(23): 2714-2716.
Tablets used to prepare recipe, and assigned a stability of 91 days at room temperature or refrigerated with Methylcellulose 1% (preserved with parabens) and Simple Syrup.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist

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