Recipe - Compounding Worksheet
Unauthorized distribution, copying or disclosure prohibited.
These recipes are intended for use by the pharmacy manufacturing departments only.
Dexamethasone Sodium Phosphate Oral Suspension in Ora-Plus® / Ora-Sweet®    1 mg/mL (Note Strength)
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    dexamethasone sodium phosphate   4 mg/mL  INJ   
    Ora-Plus® / Ora-Sweet®  1:1  SYRUP  qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. Withdraw required amount of dexamethasone and transfer to a graduated cylinder.
2. Mix Ora-Plus® and Ora-Sweet® together (1:1) to make vehicle.
3. QS to final volume with vehicle.
4. Transfer to final container and label.

Notes Ora-Blend® can be used instead of Ora-Plus® / Ora-Sweet® (1:1).

Use Dexamethasone in Normal Saline recipe for neonates corrected age 28 days or less and patients on ketogenic diet.

Can substitute dexamethasone sodium phosphate powder USP or dexamethasone tablets for injectable dexamethasone. Arbitrary expiration date of 14 days refrigerated can be assigned based on USP 795 guidelines.

March 20, 2020: In AHS dexamethasone sodium phosphate powder USP is the preferred product for compounding for the duration of the injectable dexamethasone backorder as the dexamethasone tablets are limited in supply

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Can be stored at room temperature or refrigerated
  Note Strength
  Shake Well

Storage/Expiry:Refrigerator: 91 days (prepared from injection) in amber glass or plastic bottles or plastic syringes
  Refrigerator: 14 days (prepared from powder or tablets) in amber glass or plastic bottles
  Room Temperature: 91 days (prepared from injection) in amber glass or plastic bottles

Last Date Revised: 26-Mar-20

References:Chou JW, Decarie D, Dumont RJ, Ensom MHH. Stability of dexamethasone in extemporaneously prepared oral suspensions. Can J Hosp Pharm 2001; 54(2):96-101.

Ensom M and Decarie D. Stability of extemporaneously compounded dexamethasone in glass and plastic bottles and plastic syringes. Can J Hosp Pharm 2014; 67(4): 274-279.
 
USP 34 – NF 29, 2nd Volume 1. Chapter 795: Pharmaceutical compounding – Nonsterile preparations. Rockville, MD, USA: United States Pharmacopeial Convention; 2010

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   29-Nov-2021         


This content is provided for general information purposes only. It is not intended to replace consultations with a health care professional or to provide medical advice, diagnosis or treatment. Always seek the advice of a physician or other qualified health care provider with any medical or health questions. Alberta Health Services accepts no responsibility for any modification or redistribution of this document and is not liable for any actions taken by individuals based on the information provided, or for any inaccuracies, errors, or omissions in the information in this document. These recipes are to be used as a reference and are not intended to be master formulation records. Not all recipes may be compliant with NAPRA or other standards.