Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Glycopyrrolate Oral Suspension *Note Strength*   0.5 mg/mL (500 mcg/mL)
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    glycopyrrolate USP    PWD   
    Ora-Plus® / Ora-Sweet®  1:1  SYRUP  qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. Weight out glycopyrrolate powder.
2. Mix Ora-Plus® and Ora-Sweet® together (1:1) to make vehicle.
3. Gradually levigate powder with vehicle until a liquid is formed.
4. Pour into a graduated cylinder.
5. Rinse mortar and qs to final volume with vehicle.
6. Transfer to final container and label.

Notes This recipe should be prepared ONLY in the event that the commercial product is NOT available.
NOTE: The commercial product is a different concentration (0.2 mg/mL).

Original reference used glycopyrrolate tablets to prepare recipe, but tablets are not available. Substituted tablets with powder form and reduced stability of final product as per USP 795 guidelines.

May substitute Ora-Plus® / Ora-Sweet® (1:1) with any of the following vehicles:
- Ora-Plus® / Ora-Sweet SF® (1:1)
- Ora-Blend®
- Ora-Blend SF®

Ora-Sweet SF® and Ora-Blend SF® should not be used in neonates less than or equal to 28 days corrected age.

Administering chocolate syrup before medication administration or mixing the preparation with chocolate syrup (1:1 v/v) immediately before administration is recommended to mask the bitter aftertaste of the medication, especially for children.

Packaging: 100 mL Amber Plastic Bottle

Auxiliary Labels: Note Strength
  Shake Well
  Store at Room Temperature

Storage/Expiry:Room Temperature: 30 days

Last Date Revised: 12-Jun-18

References:USP 34 – NF 29, 2nd Volume 1. Chapter 795: Pharmaceutical compounding – Nonsterile preparations. Rockville, MD, USA: United States Pharmacopeial Convention; 2010

Cober MP, Johnson CE, Sudekum D, Penprase K. Stability of extemporaneously prepared glycopyrrolate oral suspensions. Am J Health-Syst Pharm 2011; 68 (May):843-845.

Formulations: Glycopyrrolate 0.5-mg/mL oral liquid. International Journal of Pharmaceutical Compounding 2011; 15(4):337.

Formulations: Glycopyrrolate 0.5-mg/mL oral liquid. International Journal of Pharmaceutical Compounding 2007; 11(3):245.

Formulations: Glycopyrrolate 0.5-mg/mL oral liquid. International Journal of Pharmaceutical Compounding 2004; 8(3):218.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   6-Dec-2021         


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