Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Sodium BICARBONATE Topical Solution    1 mEq/mL (8.4%)
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    sodium bicarbonate, USP    PWD   
    Water, sterile       qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. Weigh out sodium bicarbonate powder.
2. In a mortar, dissolve sodium bicarbonate powder in a portion of sterile water.
3. Pour into a graduated cylinder.
4. QS to final volume with water.
5. Transfer to amber glass bottle and label.

Notes TOPICAL USE
This recipe should be used to prepare sodium hypochlorite topical solutions (in situations where there is a shortage of the sodium bicarbonate injectable product ONLY).

Note: 1 mEq/mL = 1 mmol/mL

A 14 day room temperature expiry date can be assigned for this recipe if stored in plastic containers based on information extrapolated from DiGiacinto reference.
Amber glass bottles preferred storage container.


Packaging:  Amber Glass Bottle

Auxiliary Labels: For External Use Only
  Store at Room Temperature

Storage/Expiry:Room Temperature: 30 days

Last Date Revised: 22-Jun-17

References:Nahata MC, Pai VB & Hipple TF. Pediatric Drug Formulations. Fifth ed. Cincinnati, Ohio: Havey Whitney Books Company; 2003: 254.

Formulations: Sodium Bicarbonate 8.4% injection USP. International Journal of Pharmaceutical Compounding 2003; 7(2):142.

DiGiacinto JL. Olsen KM. Bergman KL. Hoie EB. Stability of suspension formulations of lansoprazole and omeprazole stored in amber-colored plastic oral syringes. Annals of Pharmacotherapy 2000; 34:600-605.
Omeprazole suspensions prepared with sodium bicarbonate solution are stable for 14 days at room temperature in plastic containers - use this information to assign 14 day room temperature expiry to sodium bicarbonate solutions stored in plastic containers.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   6-Dec-2021         


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