Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Dexamethasone Sodium Phosphate Oral Suspension in Ora-Plus® / Ora-Sweet®    0.2 mg/mL (LOW STRENGTH)
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    dexamethasone  4 mg/mL  INJ   
    Ora-Plus® / Ora-Sweet®  1:1  SYRUP  qs to  
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. Withdraw required amount of dexamethasone and transfer to a graduated cylinder.
2. Mix Ora-Plus® and Ora-Sweet® together (1:1) to make vehicle.
3. QS to final volume with vehicle.
4. Transfer to final container and label.

If the dexamethasone injectable product is not available, the Dexamethasone Sodium Phosphate in Ora-Plus® / Ora-Sweet® 1 mg/mL Oral Suspension product can be diluted to create a 0.2 mg/mL suspension as follows:

1. In a 25 mL graduated cylinder measure 4 mL (4 mg) of the 1 mg/mL Dexamethasone Sodium Phosphate in Ora-Plus® / Ora-Sweet® Oral Suspension.

2. In a second graduated measure, add 8 mL of Ora-Plus® to 8 mL of Ora-Sweet® to create 16 mL of total vehicle (1:1). Stir well.

3. Add 16 mL of vehicle to first graduated cylinder containing 4 mg (4mL) of dexamethasone suspension, to make a total volume of 20mL. Stir well.

4. Transfer the suspension to an amber plastic bottle.

5. Label as "Dexamethasone Sodium Phosphate Oral Suspension in Ora-Plus® / Ora-Sweet® 0.2 mg/mL (LOW STRENGTH)" with "Note Strength","Refrigerate",and "Shake Well" auxillary labels

The Storage/BUD will be maintained from the 1 mg/mL stock bottle used (should not exceed a beyond use date of 14 days).

Notes Ora-Blend® can be used instead of Ora-Plus® / Ora-Sweet® (1:1).

This formulation is extrapolated from the Dexamethasone 1 mg/mL oral suspension in Ora-Plus® / Ora-Sweet® recipe. (see Reference Section).

THIS FORMULATION IS NOT BASED ON LITERATURE, but is extrapolated from information found in the references and is a modified version of the dexamethasone 1 mg/mL oral suspension in Ora-Plus® / Ora-Sweet® recipe.

Can substitute dexamethasone tablets for injectable dexamethasone.


March 20, 2020: In AHS dexamethasone sodium phosphate powder USP is the preferred product for compounding for the duration of the injectable dexamethasone backorder as the dexamethasone tablets are limited in supply


Arbitrary expiration date of 14 days REF can be assigned based on USP 795 guidelines (Pharmaceutical Compounding — Nonsterile Preparations).

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Note Strength
  Refrigerate
  Shake Well

Storage/Expiry:Refrigerator: 14 days

Last Date Revised: 26-Mar-20

References:USP 40 - NF 35. Chapter 795: Pharmaceutical compounding – Nonsterile preparations. Rockville, MD, USA: United States Pharmacopeial Convention; 2017

Chou JW, Decarie D, Dumont RJ, Ensom MHH. Stability of dexamethasone in extemporaneously prepared oral suspensions. Can J Hosp Pharm 2001; 54(2):96-101.
Reference provides a recipe for Dexamethasone 1 mg/mL oral suspension.

Ensom M and Decarie D. Stability of extemporaneously compounded dexamethasone in glass and plastic bottles and plastic syringes. Can J Hosp Pharm 2014; 67(4): 274-279.
Reference provides a recipe for Dexamethasone 1 mg/mL oral suspension.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   29-Nov-2021         


This content is provided for general information purposes only. It is not intended to replace consultations with a health care professional or to provide medical advice, diagnosis or treatment. Always seek the advice of a physician or other qualified health care provider with any medical or health questions. Alberta Health Services accepts no responsibility for any modification or redistribution of this document and is not liable for any actions taken by individuals based on the information provided, or for any inaccuracies, errors, or omissions in the information in this document. These recipes are to be used as a reference and are not intended to be master formulation records. Not all recipes may be compliant with NAPRA or other standards.