Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Imatinib Oral Suspension   40 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    imatinib  400 mg  TAB   
    Ora-Sweet® vehicle      qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: HAZARDOUS - Known
Refer to the AHS Hazardous Medication Handling Guide for more information.

1. In a mortar, crush tablets and triturate to a fine powder.
2. Gradually levigate powder with Ora-Sweet® vehicle until a liquid is formed.
3. Pour into a graduated cylinder.
4. Rinse mortar and qs to final volume with vehicle.
5. Transfer to final container and label. Mix well.

Notes Recipe can also be prepared with imatinib 100 mg tablets.

The insoluble film specks in the final suspension do not affect the stability of the final product

Microbiological testing, and bioavailability and therapeutic equivalence of the formulation was not performed by the authors in the reference study.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Antineoplastic Agent
  CHEMOTHERAPY Dispose of Properly
  Can be stored at room temperature or refrigerated
  Hazardous medication - use safe handling precautions
  Shake Well

Storage/Expiry:Refrigerator or Room Temperature: 14 days

Last Date Revised: 17-May-18

References: AHS Hazardous Medication Handling information available on Insite:

Formulations: Imatinib 40-mg/mL oral suspension. International Journal of Pharmaceutical Compounding 2016; 20(6):510.

Quan Li, et al. Stability of extemporaneous erlotinib, lapatinib, and imatinib oral suspensions. Am J Health-Syst Pharm. 2016; 73:1331-7.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist

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