Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Caffeine Base Oral Solution (prepared from anhydrous caffeine)   10 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    caffeine anhydrous, USP    PWD   
    Citric acid, anhydrous USP    PWD   
    glycerin  100%  PO SOLN   
    Water, sterile       qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. Dissolve the citric acid anhydrous powder in a portion of sterile water until clear.
2. Then add caffeine anhydrous powder.
3. Gradually levigate powder mixture with glycerin and mix well.
4. Pour into a graduated cylinder.
5. QS to final volume with sterile water.
6. Transfer to final container and label.

Notes Caffeine base 10 mg/mL = caffeine citrate 20 mg/mL

Original referenced recipe used glycerol. Due to availability, glycerin has been substituted and is equivalent to glycerol. Use a glycerin product as close to 100% glycerin as available.

Observe product for precipitation. If precipitate is observed, bring product to room temperature and shake until clear. Remaining product should be stored in refrigerator to retain BUD.

If repackaging to oral syringes, check stock bottle for precipitate prior to unit dosing. If precipitate is observed, bring stock bottle to room temperature and shake until clear prior to unit dosing. It has been recommended to store unit dose supply at room temperature and limit total dispensed unit dose quantity to a 24 hour supply.

Packaging:  Amber Plastic Bottle

Auxiliary Labels: Refrigerate
  Shake Well

Storage/Expiry:Refrigerator: 30 days

Last Date Revised: 25-Jan-21

References:Woods DJ. Formulation in pharmacy practice. 2nd edition, Dunedin, New Zealand. Available from:
http://www.fshealth.gov.za/subsites/DWoods/home.html

http://www.fshealth.gov.za/subsites/DWoods/mixtures/caffeine_citrate.html

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   29-Nov-2021         


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