||HAZARDOUS - CYTOTOXIC
Prepare in BSC and refer to the AHS Hazardous Medication Handling Guide for more information.
1. Dilute the desired amount of etoposide 20 mg/mL injectable solution with normal saline 0.9% solution for injection to 10 mg/mL.
2. Transfer to final container
||To account for product loss during transfer into oral syringes, consider making double the required amount.
Large quantities may be prepared by mixing in a glass amber bottle and using adapt-a-cap to draw up each dose in an oral syringe. Alternatively, a syringe-to-syringe tip connector may be used to mix using syringe-to-syringe transfer for mixing of a single dose.
Package final product in such a manner that allows for safe dispensing /storage of a cytotoxic medication.
||or oral syringes Amber Plastic Bottle
||CHEMOTHERAPY Dispose of Properly|
||Store at Room Temperature
|Storage/Expiry:||Room Temperature: 22 days|
|Last Date Revised:
|References:||McLeod HL, Relling MV. Stability of etoposide solution for oral use. Am J Hosp Pharm. 1992; 49:2784-5|
Lam MS : Extemporaneous compounding of oral liquid dosage formulations and alternative drug delivery methods for anticancer drugs. Pharmacotherapy 2011; 31(2):164-192.