Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Etoposide Oral Solution   10 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    etoposide injection  20 mg/mL  VIAL   
    sodium chloride  0.9%  INJ   
Recipe Total Quantity:
Final Quantity Desired: mL

Prepare in BSC and refer to the AHS Hazardous Medication Handling Guide for more information.

1. Dilute the desired amount of etoposide 20 mg/mL injectable solution with normal saline 0.9% solution for injection to 10 mg/mL.
2. Transfer to final container

Notes To account for product loss during transfer into oral syringes, consider making double the required amount.

Large quantities may be prepared by mixing in a glass amber bottle and using adapt-a-cap to draw up each dose in an oral syringe. Alternatively, a syringe-to-syringe tip connector may be used to mix using syringe-to-syringe transfer for mixing of a single dose.

Package final product in such a manner that allows for safe dispensing /storage of a cytotoxic medication.

Packaging: or oral syringes Amber Plastic Bottle

Auxiliary Labels: CHEMOTHERAPY Dispose of Properly
  Store at Room Temperature

Storage/Expiry:Room Temperature: 22 days

Last Date Revised: 26-Jun-19

References:McLeod HL, Relling MV. Stability of etoposide solution for oral use. Am J Hosp Pharm. 1992; 49:2784-5

Lam MS : Extemporaneous compounding of oral liquid dosage formulations and alternative drug delivery methods for anticancer drugs. Pharmacotherapy 2011; 31(2):164-192.

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist

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