Recipe - Compounding Worksheet
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These recipes are intended for use by the pharmacy manufacturing departments only.
Nitrazepam Oral Suspension (in Medisca Oral Mix or Medisca Oral Mix-SF)   1 mg/mL
Lot No Expiry(mm/yyyy) Ingredients Master Formula
    nitrazepam  5 mg  TAB   
    Medisca Oral Mix (Flavored Suspending Vehicle)    LIQ  qs to 
Recipe Total Quantity:
Final Quantity Desired: mL

Directions: 1. Place nitrazepam tablets into the mortar. Let soak with a bit of vehicle to soften tablets.

2. Levigate the tablets to get a smooth paste, add more vehicle if needed. Add small quantities of vehicle until a liquid is formed. Transfer the contents of the mortar to the graduated measure. Use additional vehicle to rinse remaining drug from the mortar.

3. Make up the final volume using more vehicle. Stir well.

4. Transfer the suspension to an amber bottle.

5. Label.

Notes Apo/AA Pharma brand nitrazepam tablets were used in the study supporting this recipe

May substitute Medisca Oral Mix with Medisca Oral Mix-SF
Ora Blend® and Ora-Plus® / Ora-Sweet® (1:1) cannot be substituted in this recipe as stability studies using these vehicles have not been done.

Packaging: 100 mL Amber Plastic Bottle

Auxiliary Labels: Shake Well
  Store at Room Temperature

Storage/Expiry:Room Temperature: 90 days

Last Date Revised: 11-Aug-20

References:SickKids Compounding Service. Toronto, ON: The Hospital for Sick Children. c1999 – [18-March-2020]. Available from: http://www.sickkids.ca/Pharmacy/Compounding-Service/index.html Nitrazepam 1 mg/mL oral suspension recipe (last updated Nov 2015).

Completed Compound Check
Lot NoDate Prepared Expiry DateTechnicianPharmacist
   6-Dec-2021         


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